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Expression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma

DC FieldValueLanguage
dc.contributor.author구자승-
dc.contributor.author김지원-
dc.contributor.author윤진숙-
dc.date.accessioned2017-02-24T03:26:08Z-
dc.date.available2017-02-24T03:26:08Z-
dc.date.issued2016-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146344-
dc.description.abstractPURPOSE: To investigate the difference of expression of autophagy and reactive oxygen species (ROS) related proteins in adenoid cystic carcinoma (ACC) of lacrimal gland in comparison with ACC of salivary gland. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue samples from patients pathologically diagnosed as lacrimal gland ACC (n=11) and salivary gland ACC (n=64) were used. Immunochemistry was used to measure expression of autophagy related proteins [beclin-1, light chain (LC) 3A, LC3B, p62, and BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)] and ROS related proteins [catalase, thioredoxinreductase, glutathione S-transferasepi (GSTpi), thioredoxin interacting protein, and manganese superoxide dismutase (MnSOD)]. The prognostic factors related to disease-free and overall survival (OS) in lacrimal gland ACC by log-rank tests, were determined. RESULTS: GSTpi in stromal cells was more highly expressed in lacrimal gland ACC (p=0.006), however, MnSOD in epithelial cells was expressed more in salivary gland ACC (p=0.046). LC3B positivity and BNIP3 positivity in epithelial component were associated with shorter disease-free survival (both p=0.002), and LC3A positivity in stromal component was the factor related to shorter OS (p=0.005). CONCLUSION: This is the first study to demonstrate the expression of autophagy and ROS related proteins in lacrimal gland ACC in comparison with the salivary gland ACC, which would provide a basis for further study of autophagy and ROS mechanism as novel therapeutic targets in lacrimal gland ACC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent482~489-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAutophagy*-
dc.subject.MESHBeclin-1-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHCarcinoma, Adenoid Cystic/metabolism*-
dc.subject.MESHCarcinoma, Adenoid Cystic/pathology-
dc.subject.MESHCarrier Proteins-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHLacrimal Apparatus/metabolism-
dc.subject.MESHLacrimal Apparatus/pathology-
dc.subject.MESHLacrimal Apparatus Diseases/metabolism*-
dc.subject.MESHLacrimal Apparatus Diseases/pathology-
dc.subject.MESHMale-
dc.subject.MESHMembrane Proteins-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProto-Oncogene Proteins-
dc.subject.MESHReactive Oxygen Species/metabolism*-
dc.subject.MESHSalivary Gland Neoplasms/metabolism-
dc.subject.MESHSalivary Gland Neoplasms/pathology*-
dc.subject.MESHSalivary Glands/pathology-
dc.titleExpression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorJi Won Kim-
dc.contributor.googleauthorJin Sook Yoon-
dc.identifier.doi10.3349/ymj.2016.57.2.482-
dc.contributor.localIdA00198-
dc.contributor.localIdA04544-
dc.contributor.localIdA02611-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid26847304-
dc.subject.keywordAdenoid cystic carcinoma-
dc.subject.keywordautophagy-
dc.subject.keywordlacrimal gland-
dc.subject.keywordreactive oxygen species-
dc.subject.keywordsalivary gland-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Ji Won-
dc.contributor.alternativeNameYoon, Jin Sook-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Ji Won-
dc.contributor.affiliatedAuthorYoon, Jin Sook-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume57-
dc.citation.number2-
dc.citation.startPage482-
dc.citation.endPage489-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.57(2) : 482-489, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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