Cited 4 times in
Expression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구자승 | - |
dc.contributor.author | 김지원 | - |
dc.contributor.author | 윤진숙 | - |
dc.date.accessioned | 2017-02-24T03:26:08Z | - |
dc.date.available | 2017-02-24T03:26:08Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146344 | - |
dc.description.abstract | PURPOSE: To investigate the difference of expression of autophagy and reactive oxygen species (ROS) related proteins in adenoid cystic carcinoma (ACC) of lacrimal gland in comparison with ACC of salivary gland. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue samples from patients pathologically diagnosed as lacrimal gland ACC (n=11) and salivary gland ACC (n=64) were used. Immunochemistry was used to measure expression of autophagy related proteins [beclin-1, light chain (LC) 3A, LC3B, p62, and BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)] and ROS related proteins [catalase, thioredoxinreductase, glutathione S-transferasepi (GSTpi), thioredoxin interacting protein, and manganese superoxide dismutase (MnSOD)]. The prognostic factors related to disease-free and overall survival (OS) in lacrimal gland ACC by log-rank tests, were determined. RESULTS: GSTpi in stromal cells was more highly expressed in lacrimal gland ACC (p=0.006), however, MnSOD in epithelial cells was expressed more in salivary gland ACC (p=0.046). LC3B positivity and BNIP3 positivity in epithelial component were associated with shorter disease-free survival (both p=0.002), and LC3A positivity in stromal component was the factor related to shorter OS (p=0.005). CONCLUSION: This is the first study to demonstrate the expression of autophagy and ROS related proteins in lacrimal gland ACC in comparison with the salivary gland ACC, which would provide a basis for further study of autophagy and ROS mechanism as novel therapeutic targets in lacrimal gland ACC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 482~489 | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Autophagy* | - |
dc.subject.MESH | Beclin-1 | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Carcinoma, Adenoid Cystic/metabolism* | - |
dc.subject.MESH | Carcinoma, Adenoid Cystic/pathology | - |
dc.subject.MESH | Carrier Proteins | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lacrimal Apparatus/metabolism | - |
dc.subject.MESH | Lacrimal Apparatus/pathology | - |
dc.subject.MESH | Lacrimal Apparatus Diseases/metabolism* | - |
dc.subject.MESH | Lacrimal Apparatus Diseases/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Proteins | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proto-Oncogene Proteins | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.subject.MESH | Salivary Gland Neoplasms/metabolism | - |
dc.subject.MESH | Salivary Gland Neoplasms/pathology* | - |
dc.subject.MESH | Salivary Glands/pathology | - |
dc.title | Expression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Ji Won Kim | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.identifier.doi | 10.3349/ymj.2016.57.2.482 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04544 | - |
dc.contributor.localId | A02611 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 26847304 | - |
dc.subject.keyword | Adenoid cystic carcinoma | - |
dc.subject.keyword | autophagy | - |
dc.subject.keyword | lacrimal gland | - |
dc.subject.keyword | reactive oxygen species | - |
dc.subject.keyword | salivary gland | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Ji Won | - |
dc.contributor.alternativeName | Yoon, Jin Sook | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Kim, Ji Won | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Sook | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 57 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 482 | - |
dc.citation.endPage | 489 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(2) : 482-489, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47853 | - |
dc.type.rims | ART | - |
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