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Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans

 Su Jin Jeong  ;  Sang Hoon Han  ;  Chang Oh Kim  ;  Jun Yong Choi  ;  Young Goo Song  ;  June Myung Kim 
 Geriatrics & Gerontology International, Vol.16(1) : 21-27, 2016 
Journal Title
 Geriatrics & Gerontology International 
Issue Date
Activities of Daily Living* ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood* ; Body Mass Index ; CD4-CD8 Ratio ; Cytomegalovirus/immunology* ; Essential Hypertension ; Female ; Health Status ; Humans ; Hypertension/blood ; Hypertension/physiopathology* ; Hypertension/virology* ; Immunoglobulins/blood* ; Male ; Prospective Studies ; Republic of Korea
antibody ; cytomegalovirus ; elderly patients ; functional status ; hypertension
AIM: To evaluate the relationship between human cytomegalovirus (HCMV) antibody status, and hypertension and functional status among elderly Koreans. METHODS: Patients aged ≥65 years were prospectively enrolled from March 2011 to February 2012 at a 2000-bed university hospital. We collected data including CD4+ and CD8+ T-lymphocyte count, and functional status by measuring basic activities of daily living and instrumental activities of daily living for all patients. In addition, HCMV immunoglobulin G levels were analyzed using enzyme-linked fluorescent assay. RESULTS: During the study period, 103 patients (51 men), who were admitted for treatment of infections or other diseases, were enrolled. Multivariate analysis showed that body mass index and HCMV immunoglobulin G antibody titers were independent factors associated with hypertension in elderly patients (OR 1.347, 95% CI 1.113-1.630, P = 0.002; OR 1.023, 95% CI 1.001-1.047, P = 0.042, respectively). In univariate linear correlations, HCMV antibody levels were positively correlated with systolic blood pressure levels (r = 0.303, P = 0.002), CD8+ T-lymphocyte count (r = 0.313, P = 0.001) and instrumental activities of daily living scores (r = 0.217, P = 0.028). In addition, HCMV immunoglobulin G titers were inversely associated with estimated glomerular filtration rate (r = -0.268, P = 0.006). These four variables remained independently significant in multivariate correlation analysis. CONCLUSION: These findings could provide insight into the important role of HCMV in the pathogenesis of essential hypertension and decreased functional status in the elderly.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김준명(Kim, June Myung)
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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