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Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans

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dc.contributor.author김준명-
dc.contributor.author송영구-
dc.contributor.author정수진-
dc.contributor.author김창오-
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.date.accessioned2017-02-24T03:25:00Z-
dc.date.available2017-02-24T03:25:00Z-
dc.date.issued2016-
dc.identifier.issn1444-1586-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146338-
dc.description.abstractAIM: To evaluate the relationship between human cytomegalovirus (HCMV) antibody status, and hypertension and functional status among elderly Koreans. METHODS: Patients aged ≥65 years were prospectively enrolled from March 2011 to February 2012 at a 2000-bed university hospital. We collected data including CD4+ and CD8+ T-lymphocyte count, and functional status by measuring basic activities of daily living and instrumental activities of daily living for all patients. In addition, HCMV immunoglobulin G levels were analyzed using enzyme-linked fluorescent assay. RESULTS: During the study period, 103 patients (51 men), who were admitted for treatment of infections or other diseases, were enrolled. Multivariate analysis showed that body mass index and HCMV immunoglobulin G antibody titers were independent factors associated with hypertension in elderly patients (OR 1.347, 95% CI 1.113-1.630, P = 0.002; OR 1.023, 95% CI 1.001-1.047, P = 0.042, respectively). In univariate linear correlations, HCMV antibody levels were positively correlated with systolic blood pressure levels (r = 0.303, P = 0.002), CD8+ T-lymphocyte count (r = 0.313, P = 0.001) and instrumental activities of daily living scores (r = 0.217, P = 0.028). In addition, HCMV immunoglobulin G titers were inversely associated with estimated glomerular filtration rate (r = -0.268, P = 0.006). These four variables remained independently significant in multivariate correlation analysis. CONCLUSION: These findings could provide insight into the important role of HCMV in the pathogenesis of essential hypertension and decreased functional status in the elderly.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent21~27-
dc.languageEnglish-
dc.publisherBlackwell Science-
dc.relation.isPartOfGERIATRICS & GERONTOLOGY INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActivities of Daily Living*-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntibodies, Viral/blood*-
dc.subject.MESHBody Mass Index-
dc.subject.MESHCD4-CD8 Ratio-
dc.subject.MESHCytomegalovirus/immunology*-
dc.subject.MESHEssential Hypertension-
dc.subject.MESHFemale-
dc.subject.MESHHealth Status-
dc.subject.MESHHumans-
dc.subject.MESHHypertension/blood-
dc.subject.MESHHypertension/physiopathology*-
dc.subject.MESHHypertension/virology*-
dc.subject.MESHImmunoglobulins/blood*-
dc.subject.MESHMale-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.titleAssociation between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans-
dc.typeArticle-
dc.publisher.locationJapan-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1111/ggi.12428-
dc.contributor.localIdA00953-
dc.contributor.localIdA02037-
dc.contributor.localIdA03638-
dc.contributor.localIdA01044-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ00943-
dc.identifier.eissn1447-0594-
dc.identifier.pmid25496508-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/ggi.12428/abstract-
dc.subject.keywordantibody-
dc.subject.keywordcytomegalovirus-
dc.subject.keywordelderly patients-
dc.subject.keywordfunctional status-
dc.subject.keywordhypertension-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.citation.volume16-
dc.citation.number1-
dc.citation.startPage21-
dc.citation.endPage27-
dc.identifier.bibliographicCitationGERIATRICS & GERONTOLOGY INTERNATIONAL, Vol.16(1) : 21-27, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47847-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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