Cited 14 times in
Time, Dose, and Volume Responses in a Mouse Pulmonary Injury Model Following Ablative Irradiation
DC Field | Value | Language |
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dc.contributor.author | 심효섭 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 조재호 | - |
dc.contributor.author | 최병욱 | - |
dc.contributor.author | 홍진우 | - |
dc.contributor.author | 이은정 | - |
dc.date.accessioned | 2017-02-24T03:23:16Z | - |
dc.date.available | 2017-02-24T03:23:16Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0341-2040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146332 | - |
dc.description.abstract | PURPOSE: We aimed to determine the time, dose, and volume responses in a mouse pulmonary injury model following ablative dose focal irradiation (ADFIR) in order to better understand normal lung injury. METHODS AND MATERIALS: ADFIR was administered to the left lung of mice using a small animal micro-irradiator. Histopathological evaluation and micro-computed tomography (micro-CT) analyses were performed at 1, 2, 6, and 12 weeks after irradiation. Dose responses were tested at doses of 0-90 Gy in C57BL/6 and C3H/HeJCr mice at 6 weeks after irradiation. The volume effect was evaluated with 1-, 3-, and 5-mm diameter collimators at 1-4 weeks after 90-Gy irradiation. RESULTS: ADFIR caused gross local lung injury of the inflated lung in just 1 week, with extensive hyaline material visible in the irradiated area. The fibrosing process was initiated as early as 2 weeks after irradiation. C3H and C57 mice did not show significant differences in dose response. Six weeks after irradiation, the radiation dose-response curve had a sigmoidal shape, where the lag, log, and stationary phases occurred at <40, 50-70, and >80 Gy, respectively. ADFIR induced substantial volume-dependent structural and functional damage to the lungs, and the volume changes of lung consolidation on micro-CT correlated inversely with lung fibrosis over time. CONCLUSIONS: We determined the time, dose, and volume responses in our established small animal model, and found that lung injury was substantially accelerated and phenotypically different from that of prior studies using non-ablative hemi-thorax and complete thorax irradiation schemes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 81~90 | - |
dc.language | English, German | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | LUNG | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Lung Injury/diagnostic imaging | - |
dc.subject.MESH | Acute Lung Injury/pathology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dose-Response Relationship, Radiation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Lung/diagnostic imaging | - |
dc.subject.MESH | Lung/pathology* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C3H | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Organ Size | - |
dc.subject.MESH | Radiation Dosage | - |
dc.subject.MESH | Radiation Injuries, Experimental/diagnostic imaging | - |
dc.subject.MESH | Radiation Injuries, Experimental/pathology* | - |
dc.subject.MESH | Radiosurgery/adverse effects | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | X-Ray Microtomography | - |
dc.title | Time, Dose, and Volume Responses in a Mouse Pulmonary Injury Model Following Ablative Irradiation | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Zhen-Yu Hong | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Eun Jung Lee | - |
dc.contributor.googleauthor | Kwang Hyun Song | - |
dc.contributor.googleauthor | Byoung Wook Choi | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.contributor.googleauthor | Michael D. Story | - |
dc.identifier.doi | 10.1007/s00408-015-9825-4 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A03901 | - |
dc.contributor.localId | A04059 | - |
dc.contributor.localId | A04443 | - |
dc.contributor.localId | A03047 | - |
dc.relation.journalcode | J02173 | - |
dc.identifier.eissn | 1432-1750 | - |
dc.identifier.pmid | 26563330 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s00408-015-9825-4 | - |
dc.subject.keyword | Fibrosis | - |
dc.subject.keyword | SABR | - |
dc.subject.keyword | Small animal model | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.alternativeName | Choi, Byoung Wook | - |
dc.contributor.alternativeName | Hong, Zhen-Yu | - |
dc.contributor.alternativeName | Lee, Eun Jung | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Choi, Byoung Wook | - |
dc.contributor.affiliatedAuthor | Hong, Zhen-Yu | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jung | - |
dc.citation.volume | 194 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | LUNG, Vol.194(1) : 81-90, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 53135 | - |
dc.type.rims | ART | - |
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