121 125

Cited 2 times in

A New Flow-Diverter (the FloWise): In-Vivo Evaluation in an Elastase-Induced Rabbit Aneurysm Model

Authors
 Byung Moon Kim  ;  Dong Joon Kim  ;  Dong Ik Kim 
Citation
 Korean Journal of Radiology, Vol.17(1) : 151-158, 2016 
Journal Title
 Korean Journal of Radiology 
ISSN
 1229-6929 
Issue Date
2016
MeSH
Alloys ; Aneurysm/chemically induced* ; Aneurysm/diagnostic imaging ; Aneurysm/surgery* ; Angiography ; Animals ; Arteries/pathology ; Arteries/surgery ; Catheters ; Cerebrovascular Circulation/physiology ; Constriction, Pathologic/chemically induced ; Constriction, Pathologic/diagnostic imaging ; Constriction, Pathologic/surgery ; Disease Models, Animal* ; Humans ; Male ; Pancreatic Elastase/pharmacology* ; Platinum ; Rabbits* ; Stents/adverse effects*
Keywords
Aneurysm ; Flow diverter ; Rabbit aneurysm model
Abstract
OBJECTIVE: We aimed to evaluate the efficacy and safety of a newly developed, partially retrievable flow-diverter (the FloWise) in an elastase-induced rabbit aneurysm model. MATERIALS AND METHODS: We developed a partially retrievable flow diverter composed of 48 strands of Nitinol and platinum wire. The FloWise is compatible with any microcatheter of 0.027-inch inner diameter, and is retrievable up to 70% deployment. The efficacy and safety of the FloWise were evaluated in the elastase-induced rabbit aneurysm model. The rate of technical success (full coverage of aneurysm neck) and assessment of aneurysm occlusion and stent patency was conducted by angiograms and histologic examinations at the 1-month, 3-month, and 6-month follow-up. The patency of small arterial branches (intercostal or lumbar arteries) covered by the FloWise were also assessed in the 5 subjects. RESULTS: We attempted FloWise insertion in a total of 32 aneurysm models. FloWise placement was successful in 31 subjects (96.9%). Two stents (6.2%) were occluded at the 3-month follow-up, but there was no evidence of in-stent stenosis in other subjects. All stented aneurysms showed progressive occlusion: grade I (complete aneurysm occlusion) in 44.4% and grade II (aneurysm occlusion > 90%) in 55.6% at 1 month; grade I in 90% and II in 10% at 3 months; and grade I in 90% and II in 10% at 6 months. All small arterial branches covered by the FloWise remained patent. CONCLUSION: A newly developed, partially retrievable flow-diverter seems to be a safe and effective tool of aneurysm occlusion, as evaluated in the rabbit aneurysm model.
Files in This Item:
T201600227.pdf Download
DOI
10.3348/kjr.2016.17.1.151
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김동익(Kim, Dong Ik)
김동준(Kim, Dong Joon) ORCID logo https://orcid.org/0000-0002-7035-087X
김병문(Kim, Byung Moon) ORCID logo https://orcid.org/0000-0001-8593-6841
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146324
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse