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High pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma.

 Doh Yu Hwang  ;  Soo-Jeong Kim  ;  June-Won Cheong  ;  Yundeok Kim  ;  Ji Eun Jang  ;  Jung Yeon Lee  ;  Yoo Hong Min  ;  Woo Ick Yang  ;  Jin Seok Kim 
 Leukemia & Lymphoma, Vol.57(1) : 51-57, 2016 
Journal Title
 Leukemia & Lymphoma 
Issue Date
Adolescent ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Busulfan/administration & dosage ; Female ; Ferritins/blood* ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hepatic Veno-Occlusive Disease/diagnosis ; Hepatic Veno-Occlusive Disease/etiology* ; Humans ; Lymphoma/blood* ; Lymphoma/complications ; Lymphoma/diagnosis ; Lymphoma/therapy* ; Male ; Middle Aged ; Neoplasm Staging ; Preoperative Period ; Risk Factors ; Severity of Illness Index ; Thiotepa/administration & dosage ; Transplantation Conditioning*/adverse effects ; Transplantation, Autologous ; Young Adult
Autologous stem cell transplantation ; conditioning regimen ; malignant lymphoma ; serum ferritin ; sinusoidal obstructive syndrome
Few studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT). We retrospectively analyzed 132 malignant lymphoma patients who underwent ASCT. Intravenous busulfan-based conditioning regimens were used in 108 (81.8%) patients. The combination of heparin and ursodeoxycholic acid was used for prophylaxis of SOS. Hepatic SOS was developed in 10 (7.6%) patients at a median of 30 days post-ASCT. In nine (90.0%) patients, SOS was diagnosed after 20 days post-ASCT. Two patients developed severe SOS and eventually died from multiple organ failure. In multivariate analysis, the use of the busulfan-thiotepa conditioning regimen (p = 0.003) and a high pre-transplant serum ferritin level (≥ 950 ng/mL) (p = 0.003) were risk factors for hepatic SOS. The evaluation of pre-transplant serum ferritin may be helpful in determining the most appropriate conditioning regimen with a lower risk of SOS.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김수정(Kim, Soo Jeong) ORCID logo https://orcid.org/0000-0001-8859-3573
김윤덕(Kim, Yun Deok) ORCID logo https://orcid.org/0000-0002-5336-7936
김진석(Kim, Jin Seok) ORCID logo https://orcid.org/0000-0001-8986-8436
민유홍(Min, Yoo Hong) ORCID logo https://orcid.org/0000-0001-8542-9583
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
이정연(Lee, Jung Yoen)
장지은(Jang, Ji Eun) ORCID logo https://orcid.org/0000-0001-8832-1412
정준원(Cheong, June-Won) ORCID logo https://orcid.org/0000-0002-1744-0921
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