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High pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma.

DC Field Value Language
dc.contributor.author김수정-
dc.contributor.author김윤덕-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author양우익-
dc.contributor.author이정연-
dc.contributor.author장지은-
dc.contributor.author정준원-
dc.date.accessioned2017-02-24T03:14:57Z-
dc.date.available2017-02-24T03:14:57Z-
dc.date.issued2016-
dc.identifier.issn1042-8194-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146289-
dc.description.abstractFew studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT). We retrospectively analyzed 132 malignant lymphoma patients who underwent ASCT. Intravenous busulfan-based conditioning regimens were used in 108 (81.8%) patients. The combination of heparin and ursodeoxycholic acid was used for prophylaxis of SOS. Hepatic SOS was developed in 10 (7.6%) patients at a median of 30 days post-ASCT. In nine (90.0%) patients, SOS was diagnosed after 20 days post-ASCT. Two patients developed severe SOS and eventually died from multiple organ failure. In multivariate analysis, the use of the busulfan-thiotepa conditioning regimen (p = 0.003) and a high pre-transplant serum ferritin level (≥ 950 ng/mL) (p = 0.003) were risk factors for hepatic SOS. The evaluation of pre-transplant serum ferritin may be helpful in determining the most appropriate conditioning regimen with a lower risk of SOS.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent51~57-
dc.languageEnglish-
dc.publisherInforma Healthcare-
dc.relation.isPartOfLEUKEMIA & LYMPHOMA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/adverse effects-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use*-
dc.subject.MESHBusulfan/administration & dosage-
dc.subject.MESHFemale-
dc.subject.MESHFerritins/blood*-
dc.subject.MESHHematopoietic Stem Cell Transplantation/adverse effects-
dc.subject.MESHHepatic Veno-Occlusive Disease/diagnosis-
dc.subject.MESHHepatic Veno-Occlusive Disease/etiology*-
dc.subject.MESHHumans-
dc.subject.MESHLymphoma/blood*-
dc.subject.MESHLymphoma/complications-
dc.subject.MESHLymphoma/diagnosis-
dc.subject.MESHLymphoma/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPreoperative Period-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHThiotepa/administration & dosage-
dc.subject.MESHTransplantation Conditioning*/adverse effects-
dc.subject.MESHTransplantation, Autologous-
dc.subject.MESHYoung Adult-
dc.titleHigh pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma.-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorDoh Yu Hwang-
dc.contributor.googleauthorSoo-Jeong Kim-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorYundeok Kim-
dc.contributor.googleauthorJi Eun Jang-
dc.contributor.googleauthorJung Yeon Lee-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorJin Seok Kim-
dc.identifier.doi10.3109/10428194.2015.1041387-
dc.contributor.localIdA00633-
dc.contributor.localIdA00790-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA02300-
dc.contributor.localIdA03114-
dc.contributor.localIdA03477-
dc.contributor.localIdA03729-
dc.relation.journalcodeJ02165-
dc.identifier.eissn1029-2403-
dc.identifier.pmid25899401-
dc.identifier.urlhttp://www.tandfonline.com/doi/abs/10.3109/10428194.2015.1041387-
dc.subject.keywordAutologous stem cell transplantation-
dc.subject.keywordconditioning regimen-
dc.subject.keywordmalignant lymphoma-
dc.subject.keywordserum ferritin-
dc.subject.keywordsinusoidal obstructive syndrome-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameKim, Yun Deok-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLee, Jung Yoen-
dc.contributor.alternativeNameJang, Ji Eun-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorKim, Yun Deok-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Jung Yoen-
dc.contributor.affiliatedAuthorJang, Ji Eun-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.citation.volume57-
dc.citation.number1-
dc.citation.startPage51-
dc.citation.endPage57-
dc.identifier.bibliographicCitationLEUKEMIA & LYMPHOMA, Vol.57(1) : 51-57, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid51377-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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