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Inhibition of TGFBIp expression reduces lymphangiogenesis and tumor metastasis

DC Field Value Language
dc.contributor.author김응권-
dc.contributor.author맹용선-
dc.contributor.author최승일-
dc.date.accessioned2017-02-24T03:12:17Z-
dc.date.available2017-02-24T03:12:17Z-
dc.date.issued2016-
dc.identifier.issn0950-9232-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146276-
dc.description.abstractTransforming growth factor-β-induced protein (TGFBIp) is an extracellular matrix protein that has a role in a wide range of pathological conditions. However, the role of TGFBIp signaling in lymphangiogenesis is poorly understood. The purpose of this study was therefore to analyze the effects of TGFBIp on lymphangiogenesis and determine whether TGFBIp-related lymphangiogenesis is important for the metastasis of tumor cells. TGFBIp increased adhesion, migration, and morphologic differentiation of human lymphatic endothelial cells (LECs), consistent with an increase in lymphatic vessel sprouting in a three-dimensional lymphatic ring assay. TGFBIp also induced phosphorylation of intracellular signaling molecules SRC, FAK, AKT, JNK and ERK. TGFBIp-induced lymphatic vessel sprouting was inhibited by addition of anti-integrin β3 antibody and pharmacologic inhibitors of FAK, AKT, JNK or ERK. TGFBIp increased both CCL21 expression in LECs, a chemokine that actively recruits tumor cells expressing the cognate chemokine receptors to lymphatic vessels and LEC permeability by inducing the dissociation of VE-cadherin junctions between LECs via the activation of SRC signaling. In vivo, inhibition of TGFBIp expression in SW620 cancer cells dramatically reduced tumor lymphangiogenesis and metastasis. Collectively, our findings demonstrate that TGFBIp is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent196~205-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfONCOGENE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, CD/metabolism-
dc.subject.MESHCadherins/metabolism-
dc.subject.MESHCell Adhesion-
dc.subject.MESHCell Movement-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChemokine CCL21/metabolism-
dc.subject.MESHEndothelial Cells/metabolism*-
dc.subject.MESHEndothelial Cells/pathology-
dc.subject.MESHExtracellular Matrix Proteins/genetics-
dc.subject.MESHExtracellular Matrix Proteins/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHLymphangiogenesis/physiology*-
dc.subject.MESHLymphatic Metastasis/pathology*-
dc.subject.MESHMice, Inbred NOD-
dc.subject.MESHPermeability-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTransforming Growth Factor beta/genetics-
dc.subject.MESHTransforming Growth Factor beta/metabolism*-
dc.subject.MESHXenograft Model Antitumor Assays-
dc.subject.MESHsrc-Family Kinases/metabolism-
dc.titleInhibition of TGFBIp expression reduces lymphangiogenesis and tumor metastasis-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorY-S Maeng-
dc.contributor.googleauthorB Aguilar-
dc.contributor.googleauthorS-I Choi-
dc.contributor.googleauthorEK Kim-
dc.identifier.doi10.1038/onc.2015.73-
dc.contributor.localIdA00831-
dc.contributor.localIdA01346-
dc.contributor.localIdA04099-
dc.relation.journalcodeJ02413-
dc.identifier.eissn1476-5594-
dc.identifier.pmid25772247-
dc.identifier.urlhttp://www.nature.com/onc/journal/v35/n2/full/onc201573a.html-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameMaeng, Yong Sun-
dc.contributor.alternativeNameChoi, Seung Il-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorMaeng, Yong Sun-
dc.contributor.affiliatedAuthorChoi, Seung Il-
dc.citation.volume35-
dc.citation.number2-
dc.citation.startPage196-
dc.citation.endPage205-
dc.identifier.bibliographicCitationONCOGENE, Vol.35(2) : 196-205, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid51338-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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