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Anti-atherosclerotic effect of 3-hydroxybenzaldehyde

Authors
 임수정 
Issue Date
2015
Description
Dept. of Medical Science/석사
Abstract
Atherosclerosis is a complex vascular disease caused by thickening arterial wall, infilteration of leukocytes, abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and the formation of multiple atheromatous plaques within arteries.
3-Hydroxybenzaldehyde (3-HBA) is one of the three isomers of hydroxybenzaldehyde and water-soluble phenolic aldehyde synthesized chemically, but its therapeutic function is unknown. In this study, the inhibitory role of 3-HBA on platelet derivative growth factor-induced migration and proliferation in VSMCs was studied. In addition, 3-HBA diminished signal-transduction involved in the inhibition of platelet derivative growth factor-induced migration and proliferation. Moreover, 3-HBA attenuated platelet aggregation in both in-vivo and ex-vivo conditions and prevented tail vein thrombosis induced by ??-carrageenan injection. In these experiments, 3-HBA reduced blood aggregating velocity and length of thrombus in the tail of rats. These findings suggest a potential therapeutic role of 3-HBA in the treatment of atherosclerosis.
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Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 2. Thesis
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/145690
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