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Anti-atherosclerotic effect of 3-hydroxybenzaldehyde
DC Field | Value | Language |
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dc.contributor.author | 임수정 | - |
dc.date.accessioned | 2017-01-26T05:40:22Z | - |
dc.date.available | 2017-01-26T05:40:22Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/145690 | - |
dc.description | Dept. of Medical Science/석사 | - |
dc.description.abstract | Atherosclerosis is a complex vascular disease caused by thickening arterial wall, infilteration of leukocytes, abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and the formation of multiple atheromatous plaques within arteries. 3-Hydroxybenzaldehyde (3-HBA) is one of the three isomers of hydroxybenzaldehyde and water-soluble phenolic aldehyde synthesized chemically, but its therapeutic function is unknown. In this study, the inhibitory role of 3-HBA on platelet derivative growth factor-induced migration and proliferation in VSMCs was studied. In addition, 3-HBA diminished signal-transduction involved in the inhibition of platelet derivative growth factor-induced migration and proliferation. Moreover, 3-HBA attenuated platelet aggregation in both in-vivo and ex-vivo conditions and prevented tail vein thrombosis induced by ??-carrageenan injection. In these experiments, 3-HBA reduced blood aggregating velocity and length of thrombus in the tail of rats. These findings suggest a potential therapeutic role of 3-HBA in the treatment of atherosclerosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Anti-atherosclerotic effect of 3-hydroxybenzaldehyde | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Im, SooJung | - |
dc.type.local | Thesis | - |
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