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Serially Ordered Magnetization of Nanoclusters via Control of Various Transition Metal Dopants for the Multifractionation of Cells in Microfluidic Magnetophoresis Devices

Authors
 Byunghoon Kang  ;  Bumjoon Cha  ;  Bongsoo Kim  ;  Seungmin Han  ;  Moo-Kwang Shin  ;  Eunji Jang  ;  Hyun-Ouk Kim  ;  Seo Ryung Bae  ;  Unyong Jeong  ;  Il Moon  ;  Hye yeong Son  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 Analytical Chemistry, Vol.88(2) : 1078-1082, 2016 
Journal Title
 Analytical Chemistry 
ISSN
 0003-2700 
Issue Date
2016
MeSH
Cell Line, Tumor ; Cell Separation/instrumentation* ; Cell Separation/methods* ; Humans ; Magnetic Phenomena ; Magnetite Nanoparticles/chemistry* ; Microfluidic Analytical Techniques*/instrumentation ; Particle Size ; Surface Properties ; Transition Elements/chemistry*
Abstract
A novel method (i.e., continuous magnetic cell separation in a microfluidic channel) is demonstrated to be capable of inducing multifractionation of mixed cell suspensions into multiple outlet fractions. Here, multicomponent cell separation is performed with three different distinguishable magnetic nanoclusters (MnFe2O4, Fe3O4, and CoFe2O4), which are tagged on A431 cells. Because of their mass magnetizations, which can be ideally altered by doping with magnetic atom compositions (Mn, Fe, and Co), the trajectories of cells with each magnetic nanocluster in a flow are shown to be distinct when dragged under the same external magnetic field; the rest of the magnetic characteristics of the nanoclusters are identically fixed. This proof of concept study, which utilizes the magnetization-controlled nanoclusters (NCs), suggests that precise and effective multifractionation is achievable with high-throughput and systematic accuracy for dynamic cell separation.
Full Text
http://pubs.acs.org/doi/abs/10.1021/acs.analchem.5b04111
DOI
10.1021/acs.analchem.5b04111
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
손혜영(Son, Hye Yeong) ORCID logo https://orcid.org/0000-0001-5977-6784
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/145502
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