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개의 실험적 췌외분비부전에서 단백과 탄수화물의 흡수가 지방 흡수에 미치는 영향

Other Titles
 Biliary Tract and Pancreas : Relationship among Fat , Protein , and Carbohydrate Absorptions in Canine Exocrine Pancreatic Insufficiency 
Authors
 정준표  ;  정재복  ;  박승우  ;  이세준  ;  문병수  ;  송시영  ;  이관식  ;  이상인  ;  문영명  ;  강진경 
Citation
 Korean Journal of Gastroenterology, Vol.40(2) : 126-132, 2002 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
2002
Keywords
Exocrine pancreatic insufficiency ; Fats ; Proteins ; Carbohydrates ; Absorption
Abstract
Background/Aims: Interactions among fat, protein, and carbohydrate absorption may play a role in the treatment of steatorrhea. We determined in canine exocrine pancreatic insufficiency (EPI) whether fat, protein, and carbohydrate absorptions are dependent on the pancreatic enzyme preparation (bacterial lipase, BL; porcine lipase, PL) and whether absorption of fat is related to absorptions of protein and carbohydrate. Methods: Five dogs underwent ligation of pancreatic ducts. Then, seventy two-hour fecal balance studies were performed while a high fat meal (fat 43%) was given. Powdered BL or PL was given at doses of 0, 7,500, 15,000, and 30,000 IU. Stool fat, protein, and carbohydrate were measured and coefficients of fat (CFA), protein (CPA), and carbohydrate (CCA) absorptions were calculated. Multiple regression analysis was used for statistical analysis. Results: CFA and CPA increased preparation (PL is better than BL) and dose dependently. However, CCA increased dose-dependently but not preparation-dependently. Fat absorption increased as protein and carbohydrate absorption increased (p<0.001). Conclusions: In dogs with EPI fed a high fat diet,porcine pancreatic enzyme increases fat and protein absorption greater than bacterial lipase, and the increase of fat absorption is related to the increase of protein and carbohydrate absorptions.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jin Kyung(강진경)
Moon, Byung Soo(문병수)
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Se Joon(이세준) ORCID logo https://orcid.org/0000-0002-2695-2670
Chung, Jae Bock(정재복)
Chung, Jun Pyo(정준표)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144783
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