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기분안정기의 I 형 양극성 장애에서 신경인지기능

Other Titles
 Neurocognitive Function in the Euthymic Bipolar I Disorders 
 조현상  ;  이상민  ;  소형석  ;  송진관  ;  김지혜  ;  정혜정  ;  이충헌  ;  안석균 
 Journal of the Korean Neuropsychiatric Association (신경정신의학), Vol.41(4) : 638-648, 2002 
Journal Title
 Journal of the Korean Neuropsychiatric Association (신경정신의학) 
Issue Date
양극성 장애 ; 신경인지기능
Objectives: The previous assumption that patients with bipolar I disorder make a full recovery of cognitive function in the euthymic phase has been challenged by studies that suggest neuronal changes, and recently persisting europsychological dysfunctions beyond episodes of the illness. The aim of the present study was to investigate the impairment of the neurocognitive performance of euthymic bipolar patients, the characteristics of cognitive impairment, and the relationship between cognitive dysfunction and clinical variables of illness in bipolar population. Methods: 19 bipolar out-patients who had been euthymic for more than 3 months by Hamilton Depression Scale score below 7 and Young Mania Rating Scale score below 6 were compared with age- and education- matched 19 healthy subjects on neurocognitive tests. Patients showing observable extrapyramidal symptoms were excluded with the objective rating. The following tests were administered in according to cognitive domain: Korean-Wechsler Adult Intelligence Scale, subtests among Wechsler Memory Scale-Revised, Wisconsin Card Sorting Test, and Signal Detection/Decision-Reaction Timer/Psychomotor Performances among Vienna Test System. Results: The bipolar group performed significantly lower than the control group on verbal and performance IQ, total IQ, and psychomotor function or coordination. There was no relationship between the cognitive impairment and clinical course of illness, except duration of neuroleptic exposure. Conclusion: Although our findings did not replicate the recently reported results, especially in the domain of executive function and verbal memory, they suggested the presence of neurocognitive difficulties, in the general ability and visuomotor function in stable bipolar patients. Also, we tailed to identify the influence of clinical course variables on cognitive area with statistically signficant differences.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
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