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Laminin modified infection-preventing collagen membrane containing silver sulfardiazine-hyaluronan microparticles

Authors
 Jong Eun Lee  ;  Jong Chul Park  ;  Kwang Hoon Lee  ;  Sang Ho Oh  ;  Hwal Suh 
Citation
 Artificial Organs, Vol.26(6) : 521-528, 2002 
Journal Title
 Artificial Organs 
ISSN
 0160-564X 
Issue Date
2002
MeSH
Adjuvants, Immunologic/pharmacology* ; Adjuvants, Immunologic/therapeutic use ; Animals ; Anti-Infective Agents, Local/pharmacology* ; Anti-Infective Agents, Local/therapeutic use ; Bandages ; Collagen/pharmacology* ; Collagen/therapeutic use ; Disease Models, Animal ; Fibroblasts/drug effects* ; Guinea Pigs ; Humans ; Hyaluronic Acid/pharmacology* ; Hyaluronic Acid/therapeutic use ; In Vitro Techniques ; Infection Control* ; Laminin/pharmacology* ; Laminin/therapeutic use ; Microspheres ; Silver Sulfadiazine/pharmacology* ; Silver Sulfadiazine/therapeutic use ; Wound Healing/drug effects*
Keywords
Collagen membrane ; Silver sulfadiazine ; Hyaluronan microparticles ; Laminin ; Wound healing
Abstract
The newly developed laminin modified infection-preventing collagen membrane consists of a 3 component laminate, comprising 2 outer collagen layers and a central laminin layer. The 2 outer collagen layers (dense and porous layers) were fabricated by air-drying and freeze drying, respectively, and the laminin layer was formed by a straightforward liquid coating method. In addition, hyaluronan based microparticles containing silver sulfadiazine (AgSD) were incorporated into the 2 collagen layers (AgSD content 50 μg/cm2). Laminin coated collagen surfaces did not promote fibroblast attachment but showed a retarded fibroblast proliferation rate and an increased rate of collagen synthesis versus pure collagen surfaces. In an animal study, a laminin coating on a nonmedicated collagen membrane significantly increased both wound size reduction and vessel proliferation 7 days after application versus polyurethane film. Interestingly, the laminin coated AgSD medicated collagen membrane demonstrated higher wound size reduction and vessel proliferation and lower inflammation than the polyurethane control, suggesting that the laminin AgSD medicated collagen membrane substantially improves dermal wound healing.
Full Text
http://onlinelibrary.wiley.com/doi/10.1046/j.1525-1594.2002.06890.x/abstract
DOI
10.1046/j.1525-1594.2002.06890.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Suh, Hwal(서활)
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Kwang Hoon(이광훈)
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144587
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