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Antitumoral effects of recombinant adenovirus YKL-1001, conditionally replicating in α-fetoprotine-producing human liver cancer cells

Authors
 Jaesung Kim  ;  Boyoung Lee  ;  Jin Seok Kim  ;  Chae Ok Yun  ;  Joo Hang Kim  ;  Yong J. Lee  ;  Chul Hyun Joo  ;  Heuiran Lee 
Citation
 CANCER LETTERS, Vol.180(1) : 23-32, 2002 
Journal Title
CANCER LETTERS
ISSN
 0304-3835 
Issue Date
2002
Keywords
Hepatocellular carcinoma ; Oncolytic recombinant adenovirus ; α-Fetoprotein ; Antitumoral effect
Abstract
Selectively replicating recombinant adenovirus has emerged as a novel strategy for the treatment of incurable human cancers. One of the major characteristics of hepatocellular carcinoma is the transcriptional reactivation of α-fetoprotein (AFP). In this study, we evaluated the liver cancer-specific oncolytic potential of E1B 55kDa-deleted recombinant adenovirus (YKL-1001), which retained other E1 genes driven by the AFP promoter. Transient transfection study using luciferase indicated the selective activation of the AFP promoter only in human liver cancer cells secreting AFP (HepG2, Hep3B). YKL-1001 induced both cytopathic effects exclusively in AFP-positive liver cancer cells and the growth inhibition of pre-established Hep3B xenografts. Finally, hematoxylin–eosin staining and the immunohistochemistry to the adenoviral hexon showed a large distributed necrotic area and this implied a wide spread of YKL-1001. Therefore, the present study demonstrated that YKL-1001 holds significant promise as an oncolytic agent for hepatocellular carcinoma.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383502000174
DOI
10.1016/S0304-3835(02)00017-4
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Yun, Chae Ok(윤채옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144196
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