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Antitumoral effects of recombinant adenovirus YKL-1001, conditionally replicating in α-fetoprotine-producing human liver cancer cells

DC FieldValueLanguage
dc.contributor.author김주항-
dc.contributor.author윤채옥-
dc.date.accessioned2016-05-16T11:16:49Z-
dc.date.available2016-05-16T11:16:49Z-
dc.date.issued2002-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144196-
dc.description.abstractSelectively replicating recombinant adenovirus has emerged as a novel strategy for the treatment of incurable human cancers. One of the major characteristics of hepatocellular carcinoma is the transcriptional reactivation of α-fetoprotein (AFP). In this study, we evaluated the liver cancer-specific oncolytic potential of E1B 55kDa-deleted recombinant adenovirus (YKL-1001), which retained other E1 genes driven by the AFP promoter. Transient transfection study using luciferase indicated the selective activation of the AFP promoter only in human liver cancer cells secreting AFP (HepG2, Hep3B). YKL-1001 induced both cytopathic effects exclusively in AFP-positive liver cancer cells and the growth inhibition of pre-established Hep3B xenografts. Finally, hematoxylin–eosin staining and the immunohistochemistry to the adenoviral hexon showed a large distributed necrotic area and this implied a wide spread of YKL-1001. Therefore, the present study demonstrated that YKL-1001 holds significant promise as an oncolytic agent for hepatocellular carcinoma.-
dc.description.statementOfResponsibilityopen-
dc.format.extent23~32-
dc.relation.isPartOfCancer Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAntitumoral effects of recombinant adenovirus YKL-1001, conditionally replicating in α-fetoprotine-producing human liver cancer cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJaesung Kim-
dc.contributor.googleauthorBoyoung Lee-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorChae Ok Yun-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorYong J. Lee-
dc.contributor.googleauthorChul Hyun Joo-
dc.contributor.googleauthorHeuiran Lee-
dc.identifier.doi10.1016/S0304-3835(02)00017-4-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00945-
dc.contributor.localIdA02614-
dc.relation.journalcodeJ00448-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304383502000174-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordOncolytic recombinant adenovirus-
dc.subject.keywordα-Fetoprotein-
dc.subject.keywordAntitumoral effect-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameYun, Chae Ok-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorYun, Chae Ok-
dc.rights.accessRightsnot free-
dc.citation.volume180-
dc.citation.number1-
dc.citation.startPage23-
dc.citation.endPage32-
dc.identifier.bibliographicCitationCancer Letters, Vol.180(1) : 23-32, 2002-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Cancer Research (암연구소) > 1. Journal Papers

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