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Amoxicillin-Sulbactam (Sultamox)의 주요 임상 분리세균에 대한 시험관내 항균력

Other Titles
 In Vitro Activities of Amoxicillin-Sulbactam (Sultamox) against Major Clinical Isolates of Bacteria 
Authors
 염종화  ;  용동은  ;  김명숙  ;  이경원  ;  정윤섭 
Citation
 Journal of the Korean Society for Chemotherapy (대한화학요법학회지), Vol.20(3) : 203-212, 2002 
Journal Title
 Journal of the Korean Society for Chemotherapy (대한화학요법학회지) 
ISSN
 1225-7850 
Issue Date
2002
Abstract
Background : Q-lactam antibiotics are one of the most frequently used antimicrobial agents. However, with the increase of a-lactamase-producing bacteria, penicillins and amoxicillin have become less useful. Amoxici Ili n-sulbactam (AXS) was developed to restore the activity. The aim of this study was to determine the in vitro activities of AXS against recent clinical isolates. Methods : Various aerobic bacteria tested were isolated from clinical specimens in Severance Hospital during . 2000 to 2001 Antimicrobial susceptibility was determined by the NCCLS agar dilution method. Results : Oxacillin-susceptible Staphylococcus aureus and coagulase-negative Staphylococcus I Streptococcus pneumoniae and S. pyogenes were susceptible to ampicillin-sulbactam (APS), amoxicillin-clavulanic acid (AXC) and AXS. For Moraxella (Branhamella) catarrhalis and Haemophilus influenzae, MIC9os of APS, AXC and AXS were 0.5 ug/"mL and´ 8 ug/mL, respectively, which were 16-fold lower than those of amoxicillin. For Klebsiella oxytoca and Proteus mirabilis, MIC90 of amoxicillin was >128 Pg/mL, but M1Cgos of APS, AXC and AXS were 8-32 ug/mL and 4-16 ug/mL, respectively. Conclusion : AXS showed good antimicrobial activities against oxacilli n- susceptible Staphylococcus, M. (B.) catarrhalis, H. influenzae, K oxytoca, and P. mirabilis. Therefore, It would be useful for the treatment of infections due to these organisms.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144174
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