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국소적 간 병소의 평가에서 Gadolinium Chelate와 Mangafodipir Trisodium을 연속으로 사용하여 얻은 자기공명영상 : 영상소견과 안정성에 관한 연구

Other Titles
 MRI after Sequential Use of Gadolinium Chelate and Mangafodipir Trisodium for the Evaluation of Focal Liver Lesions: Study of Image Findings and Safety 
 정재준  ;  김명진  ;  김주희  ;  이종태  ;  유형식 
 Journal of the Korean Radiologist Society (대한방사선의학회지), Vol.46(6) : 561-567, 2002 
Journal Title
Journal of the Korean Radiologist Society(대한방사선의학회지)
Issue Date
Liver ; MR Gadolinium Manganese Magnetic resonance(MR) ; contrast enhancement
Purpose: To assess the feasibility of sequentially administering Gd-DTPA and Mn-DPDP for the MR imaging of focal hepatic lesions, and to investigate whether the procedures involved led to any adverse effects. Materials and Methods: Forty-two patients (M:F=25:17) with suspected hepatic lesions underwent T1-weighted MR imaging procedures before and after Gd-DTPA enhancement, and after sequential Mn-DPDP administration. Two investigators reviewed the findings in terms of the size, number, morphology, and enhancement patterns of the lesions. Any adverse actions resulting from the procedures were noted. Results: Fifteen patients had hepatocellular carcinoma (HCC, n=35), 13 showed liver metastases (n=40), nine had hemangioma (n=13), two had cholangiocarcinoma (CC, n=2), two had a liver abscess (n=2), and one had focal nodular hyperplasia (FNH, n=2). All focal hepatic lesions were clearly visible, with no difference in conspicuity between T1-weighted images obtained after Gd-DTPA administration and those obtained after Gd-DTPA plus Mn-DPDP administration. After the latter procedure, 12 HCCs showed high or iso- signal intensity to liver parenchyma and 23 showed no contrast enhancement. Thirty-eight liver metastases showed no contrast enhancement, but in two cases ring enhancement was observeed. In both cases of FNH, homogeneous enhancement was noted. No hemangiomas, CCs or abscesses demonstrated contrast enhancement. The only adverse reaction was five instances of facial flushing. Conclusion: Hepatic MR imaging after sequential Gd-DTPA plus Mn-DPDP administration may be selectively useful in differentiating between hepatocellular and non-hepatocellular tumor. No technical difficulties or severe adverse reactions were encountered.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Yoo, Hyung Sik(유형식)
Lee, Jong Tae(이종태)
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
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