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Characterization of focal hepatic lesions with ferumoxides-enhanced MR imaging: Utility of T1-weighted spoiled gradient recalled echo images using different echo times

 Joo Hee Kim  ;  Myeong-Jin Kim  ;  Sang Hyun Suh  ;  Jae-Joon Chung  ;  Hyung Sik Yoo  ;  Jong Tae Lee 
 Journal of Magnetic Resonance Imaging, Vol.15(5) : 573-583, 2002 
Journal Title
 Journal of Magnetic Resonance Imaging 
Issue Date
magnetic resonance imaging ; liver neoplasms ; iron oxides ; contrast media ; magnetic resonance ; pulse sequences
Purpose: To evaluate the different signal characteristics of focal hepatic lesions on ferumoxides-enhanced MR imaging, including T1-weighted spoiled gradient recalled echo (GRE) images using different echo times (TE) and T2- and T2*-weighted images. Materials and Methods Ferumoxides-enhanced MR imaging was performed using a 1.5-T system in 46 patients who were referred for evaluation of known or suspected hepatic malignancies. One hundred and seven lesions (42 hepatocellular carcinomas [HCC], 40 metastases, 13 cysts, eight hemangiomas, three focal nodular hyperplasias [FNHs], and one cholangiocarcinoma) were evaluated. Postcontrast MR imaging included 1) T2-weighted FSE; 2) T2*-weighted GRE; 3) T1-weighted spoiled GRE using moderate (TE = 4.2–4.4 msec) TE; and 4) minimum (TE = 1.8–2.1 msec) TE. Signal intensities of the focal lesions were rated by two radiologists in conference as follows: hypointense, isointense or invisible, hyperintense, and markedly hyperintense. Lesion-to-liver contrast-to-noise ratio (C/N) was measured by one radiologist for a quantitative assessment. Results On ferumoxides-enhanced FSE images, 92% of cysts were “markedly hyperintense” and most of the other lesions were “hyperintense”, and the mean C/N of cysts was significantly higher than that of other focal lesions. T2*-weighted GRE images showed most lesions with similar hyperintensities and the mean C/N was not significantly different between any two types of lesion. T1-weighted GRE images using moderate TE showed all FNHsand hemangiomas, 29 (69%) HCCs and eight (20%) metastases as “hyperintense”. On T1-weighted GRE images using minimum TE, however, all HCCs and metastasis except one were iso- or hypointense, while all of the FNHs and hemangiomas were hyperintense. Ring enhancement was highly suggestive of malignant lesions, and was more commonly seen on the minimum TE images than on the moderate TE images. Conclusion Addition of T1-weighted GRE images using minimum and moderate TE is helpful for characterizing focal lesions in ferumoxides-enhanced MR imaging.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Suh, Sang Hyun(서상현) ORCID logo https://orcid.org/0000-0002-7098-4901
Yoo, Hyung Sik(유형식)
Lee, Jong Tae(이종태)
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
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