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동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 -STR 유전자좌 분석법의 표준화 설정을 위하여-

Other Titles
 Comparison of STR Typing Results from Several Centers for the Same Samples: Steps to Standardization for STR Typing 
Authors
 박종태  ;  신경진  ;  양윤석  ;  우광만  ;  이숭덕  ;  이승환  ;  이정빈  ;  정연보  ;  조승희  ;  한길로  ;  한면수  ;  홍승범 
Citation
 Korean Journal of Legal Medicine (대한법의학회지), Vol.25(1) : 8-16, 2001 
Journal Title
Korean Journal of Legal Medicine(대한법의학회지)
ISSN
 1225-0589 
Issue Date
2001
Abstract
This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea. Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers, 2 VNTRs, 36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods and the profiling data were described.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143130
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