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Coordination of Pancreatic HCO3- Secretion by Protein-Protein Interaction between Membrane Transporters

Authors
 Min Goo Lee  ;  Wooin Ahn  ;  Jin Ah Lee  ;  Joo Young Kim  ;  Joo Young Choi  ;  Orson W Moe  ;  Sharon L Milgram  ;  Shmuel Muallem  ;  Kyung Hwan Kim 
Citation
 JOURNAL OF THE PANCREAS, Vol.2(Suppl4) : 203-206, 2001 
Journal Title
 JOURNAL OF THE PANCREAS 
Issue Date
2001
MeSH
Animals ; Bicarbonates/metabolism* ; Humans ; Membrane Transport Proteins/metabolism* ; Membrane Transport Proteins/physiology ; Pancreas/metabolism* ; Pancreas/physiology ; Protein Binding ; Protein Interaction Mapping*
Abstract
Increasing evidence suggests that protein-protein interaction is essential in many biological processes including epithelial transport. In this report, we discuss the significance of protein interactions to HCO3- secretion in pancreatic duct cells. In pancreatic ducts HCO3- secretion is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) activated luminal Cl-/HCO3- exchange activity and HCO3- absorption is achieved by Na+-dependent mechanisms including Na+/H+ exchanger 3 (NHE3). We found biochemical and functional association between CFTR and NHE3. In addition, protein binding through PDZ modules is needed for this regulatory interaction. CFTR affected NHE3 activities in two ways. Acutely, CFTR augmented the cAMP-dependent inhibition of NHE3. In a chronic mechanism, CFTR increases the luminal expression of Na+/H+ exchange in pancreatic duct cells. These findings reveal that protein complexes in the plasma membrane of pancreatic duct cells are highly organized for efficient HCO3- secretion.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143046
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