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Coordination of Pancreatic HCO3- Secretion by Protein-Protein Interaction between Membrane Transporters
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2016-02-19T11:23:37Z | - |
dc.date.available | 2016-02-19T11:23:37Z | - |
dc.date.issued | 2001 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143046 | - |
dc.description.abstract | Increasing evidence suggests that protein-protein interaction is essential in many biological processes including epithelial transport. In this report, we discuss the significance of protein interactions to HCO3- secretion in pancreatic duct cells. In pancreatic ducts HCO3- secretion is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) activated luminal Cl-/HCO3- exchange activity and HCO3- absorption is achieved by Na+-dependent mechanisms including Na+/H+ exchanger 3 (NHE3). We found biochemical and functional association between CFTR and NHE3. In addition, protein binding through PDZ modules is needed for this regulatory interaction. CFTR affected NHE3 activities in two ways. Acutely, CFTR augmented the cAMP-dependent inhibition of NHE3. In a chronic mechanism, CFTR increases the luminal expression of Na+/H+ exchange in pancreatic duct cells. These findings reveal that protein complexes in the plasma membrane of pancreatic duct cells are highly organized for efficient HCO3- secretion. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 203~206 | - |
dc.relation.isPartOf | JOURNAL OF THE PANCREAS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bicarbonates/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Membrane Transport Proteins/metabolism* | - |
dc.subject.MESH | Membrane Transport Proteins/physiology | - |
dc.subject.MESH | Pancreas/metabolism* | - |
dc.subject.MESH | Pancreas/physiology | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Protein Interaction Mapping* | - |
dc.title | Coordination of Pancreatic HCO3- Secretion by Protein-Protein Interaction between Membrane Transporters | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Min Goo Lee | - |
dc.contributor.googleauthor | Wooin Ahn | - |
dc.contributor.googleauthor | Jin Ah Lee | - |
dc.contributor.googleauthor | Joo Young Kim | - |
dc.contributor.googleauthor | Joo Young Choi | - |
dc.contributor.googleauthor | Orson W Moe | - |
dc.contributor.googleauthor | Sharon L Milgram | - |
dc.contributor.googleauthor | Shmuel Muallem | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J01898 | - |
dc.identifier.eissn | 1590-8577 | - |
dc.identifier.pmid | 11875260 | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hwan | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 2 | - |
dc.citation.number | Suppl4 | - |
dc.citation.startPage | 203 | - |
dc.citation.endPage | 206 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE PANCREAS, Vol.2(Suppl4) : 203-206, 2001 | - |
dc.identifier.rimsid | 38975 | - |
dc.type.rims | ART | - |
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