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Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats

Authors
 Tie Yuan Zhang ; Jeong Won Jahng ; Dong Goo Kim 
Citation
 Neuroscience Letters, Vol.309(2) : 85~88, 2001 
Journal Title
 Neuroscience Letters 
ISSN
 0304-3940 
Issue Date
2001
Abstract
Dextromethorphan (DM), an antitussive widely available in over-the-counter, has been abused mostly in teenage groups at high doses. To examine effects of DM on the reward pathway, we injected a high dose of DM (40 mg/kg; intraperitoneally) into the adolescent rat and measured tyrosine hydroxylase (TH) mRNA by in situ hybridization in the ventral tegmental area (VTA) and the substantia nigra (SN). Remarkable increases in the level of TH mRNA were observed in the VTA and SN 2 h after DM injection. Stereotyped behavior and ataxia increased, and rearing decreased by DM administration. These results suggest that DM-induced increase in TH mRNA expression in mesencephalon contribute to the reinforcing property and the behavioral effects of DM.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142821
DOI
10.1016/S0304-3940(01)02029-8
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pharmacology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0304394001020298
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