Cited 10 times in
Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.date.accessioned | 2016-02-19T11:17:31Z | - |
dc.date.available | 2016-02-19T11:17:31Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142821 | - |
dc.description.abstract | Dextromethorphan (DM), an antitussive widely available in over-the-counter, has been abused mostly in teenage groups at high doses. To examine effects of DM on the reward pathway, we injected a high dose of DM (40 mg/kg; intraperitoneally) into the adolescent rat and measured tyrosine hydroxylase (TH) mRNA by in situ hybridization in the ventral tegmental area (VTA) and the substantia nigra (SN). Remarkable increases in the level of TH mRNA were observed in the VTA and SN 2 h after DM injection. Stereotyped behavior and ataxia increased, and rearing decreased by DM administration. These results suggest that DM-induced increase in TH mRNA expression in mesencephalon contribute to the reinforcing property and the behavioral effects of DM. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 85~88 | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dextromethorphan/pharmacology* | - |
dc.subject.MESH | Excitatory Amino Acid Antagonists/pharmacology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Enzymologic/drug effects | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | RNA, Messenger/analysis | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Substance-Related Disorders/metabolism | - |
dc.subject.MESH | Substantia Nigra/drug effects* | - |
dc.subject.MESH | Substantia Nigra/enzymology | - |
dc.subject.MESH | Tyrosine 3-Monooxygenase/genetics* | - |
dc.subject.MESH | Ventral Tegmental Area/drug effects* | - |
dc.subject.MESH | Ventral Tegmental Area/enzymology | - |
dc.title | Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Tie Yuan Zhang | - |
dc.contributor.googleauthor | Jeong Won Jahng | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.identifier.doi | 10.1016/S0304-3940(01)02029-8 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00396 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 11502351 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304394001020298 | - |
dc.subject.keyword | Dextromethorphan | - |
dc.subject.keyword | Tyrosine hydroxylase | - |
dc.subject.keyword | Ventral tegmental area | - |
dc.subject.keyword | Substantia nigra | - |
dc.subject.keyword | Drug abuse | - |
dc.subject.keyword | Behavior | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 309 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 88 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.309(2) : 85-88, 2001 | - |
dc.identifier.rimsid | 29877 | - |
dc.type.rims | ART | - |
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