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Effect of Botulinum Toxin A Chemodnervation in Sensory Strabismus

 Han  ;  Sueng Han  ;  Lew  ;  Helen  ;  Jeong  ;  Chang Woog  ;  Lee  ;  Jong Bok 
 Journal of Pediatric Ophthalmology & Strabismus, Vol.38(2) : 68-71, 2001 
Journal Title
 Journal of Pediatric Ophthalmology & Strabismus 
Issue Date
To study the effect of botulinum toxin type A chemodenervation in sensory strabismus. Twelve patients with sensory strabismus were treated with an injection of botulinum toxin type A (Botox; Allergan, Irvine, Calif). Botulinum toxin type A was diluted with 0.9% sodium chloride without preservative at a dose that ranged from 1.25-5 U. A Teflon-coated needle electrode was inserted into the medial rectus muscle in cases of esotropia and into the lateral rectus muscle in cases of exotropia. Four patients were treated with > or =2 injections of botulinum toxin type A. Changes in the angle of strabismus and related complications were followed for >6 months postinjection. The mean deviation before injection was 33.8 prism diopters (delta) and the mean corrective effect on the deviation was 72.8% after injection in patients with sensory strabismus. The final deviation in 9 patients was <10 delta. Complications were hypertropia in 3 (25%) patients and conjunctival hemorrhage in 1 (8.3%) patient. Botulinum toxin type A is likely to prevent muscle contracture and affect muscle and neuronal tissues. This study on the effects of sensory strabismus with botulinum toxin type A injection suggests it has the potential to replace surgery or be used as an adjuvant therapy.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
Yonsei Authors
이종복(Lee, Jong Bok)
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