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Effect of Botulinum Toxin A Chemodnervation in Sensory Strabismus

Authors
 Han  ;  Sueng Han  ;  Lew  ;  Helen  ;  Jeong  ;  Chang Woog  ;  Lee  ;  Jong Bok 
Citation
 JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS, Vol.38(2) : 68-71, 2001 
Journal Title
 JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS 
ISSN
 0191-3913 
Issue Date
2001
MeSH
Adult ; Botulinum Toxins, Type A* ; Female ; Humans ; Male ; Middle Aged ; Muscle Denervation/methods* ; Neuromuscular Agents* ; Oculomotor Muscles/innervation* ; Strabismus/therapy* ; Sympathectomy, Chemical/methods* ; Treatment Outcome ; Vision, Binocular
Abstract
To study the effect of botulinum toxin type A chemodenervation in sensory strabismus. Twelve patients with sensory strabismus were treated with an injection of botulinum toxin type A (Botox; Allergan, Irvine, Calif). Botulinum toxin type A was diluted with 0.9% sodium chloride without preservative at a dose that ranged from 1.25-5 U. A Teflon-coated needle electrode was inserted into the medial rectus muscle in cases of esotropia and into the lateral rectus muscle in cases of exotropia. Four patients were treated with > or =2 injections of botulinum toxin type A. Changes in the angle of strabismus and related complications were followed for >6 months postinjection. The mean deviation before injection was 33.8 prism diopters (delta) and the mean corrective effect on the deviation was 72.8% after injection in patients with sensory strabismus. The final deviation in 9 patients was <10 delta. Complications were hypertropia in 3 (25%) patients and conjunctival hemorrhage in 1 (8.3%) patient. Botulinum toxin type A is likely to prevent muscle contracture and affect muscle and neuronal tissues. This study on the effects of sensory strabismus with botulinum toxin type A injection suggests it has the potential to replace surgery or be used as an adjuvant therapy.
Full Text
http://search.proquest.com/docview/222170489?accountid=131089
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jong Bok(이종복)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142819
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