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Comparisons of Intraocular-Pressure- Lowering Efficacy and Side Effects of 2% Dorzolamide and 1% Brinzolamide

Authors
 Seong G.J.  ;  Lee S.C.  ;  Lee J.H.  ;  Chu Y.K.  ;  Hong Y.J. 
Citation
 OPHTHALMOLOGICA, Vol.215(3) : 188-191, 2001 
Journal Title
 OPHTHALMOLOGICA 
ISSN
 0030-3755 
Issue Date
2001
MeSH
Adult ; Carbonic Anhydrase Inhibitors/adverse effects ; Carbonic Anhydrase Inhibitors/pharmacology* ; Double-Blind Method ; Female ; Humans ; Intraocular Pressure/drug effects* ; Male ; Ophthalmic Solutions ; Safety ; Sulfonamides/adverse effects ; Sulfonamides/pharmacology* ; Thiazines/adverse effects ; Thiazines/pharmacology* ; Thiophenes/adverse effects ; Thiophenes/pharmacology* ; Tonometry, Ocular
Keywords
Dorzolamide ; Brinzolamide ; Intraocular pressure ; Side effects
Abstract
Forty-one healthy volunteers were recruited for a study to compare the intraocular pressure (IOP)-lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide. In a randomized double-blind design, one eye received one drop of 2% dorzolamide and the other eye received one drop of 1% brinzolamide. The IOP and side effects were evaluated by Goldmann applanation tonometry and slit lamp biomicroscopy before administration, and 3, 7 and 14 days after the initial administration of eyedrops. The IOP decreased significantly from baseline for both drugs (p < 0.05). However, there were no statistically significant differences between 2% dorzolamide and 1% brinzolamide either before or after eyedrop administration (p > 0.05). The most frequent side effect was ocular pain in the case of 2% dorzolamide and blurred vision in 1% brinzolamide. The results suggested that 2% dorzolamide and 1% brinzolamide have similar IOP-lowering efficacies with different side effects
Full Text
http://www.karger.com/Article/FullText/50856
DOI
10.1159/000050856
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142816
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