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Hepatic iron deposition on MR imaging in patients with chronic liver disease: correlation with serial serum ferritin concentration

Authors
 M.-J. Kim  ;  D. G. Mitchell  ;  K. Ito  ;  H.-W. L. Hann  ;  Y. N. Park  ;  P. N. Kim 
Citation
 ABDOMINAL IMAGING, Vol.26(2) : 149-156, 2001 
Journal Title
 ABDOMINAL IMAGING 
ISSN
 0942-8925 
Issue Date
2001
MeSH
Adult ; Aged ; Carcinoma, Hepatocellular/metabolism ; Chronic Disease ; Female ; Ferritins/blood* ; Hepatitis, Viral, Human/blood ; Hepatitis, Viral, Human/metabolism* ; Humans ; Iron/analysis* ; Liver/chemistry* ; Liver Cirrhosis/blood ; Liver Cirrhosis/metabolism* ; Liver Neoplasms/metabolism ; Magnetic Resonance Imaging* ; Male ; Middle Aged ; Observer Variation ; Spleen/chemistry
Keywords
liver ; MR imaging ; Ferritin
Abstract
BACKGROUND: To evaluate the relationship between magnetic resonance (MR) imaging grading of iron deposition and serial serum ferritin concentration in patients with chronic viral liver diseases. METHODS: In 80 patients with viral hepatitis and cirrhosis, MR images including T2*-weighted gradient echo images (echo time > or = 6.5 ms) were reviewed. The grades of parenchymal iron deposition and iron-containing nodules in the liver and spleen and the liver-to-muscle and spleen-to-muscle signal intensity ratios were compared with the most recent, the mean, the lowest, and the highest values from all available serum ferritin levels. RESULTS: The serum ferritin concentration was significantly correlated with the grades of iron deposition in liver and spleen and with the grades of iron-containing nodules seen on MR images (p < 0.05). Liver-to-muscle signal intensity ratio was weakly correlated with the ferritin concentrations. Among categories of ferritin concentration, correlation with MR grades was highest for mean ferritin concentration (r = 0.487, p < 0.001). CONCLUSION: MR imaging grades of hepatic iron and siderotic nodules correlate with serum ferritin, especially with the mean levels.
Full Text
http://link.springer.com/article/10.1107/s002610000121
DOI
10.1107/s002610000121
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142432
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