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Dependence of Malformation upon Gestational Age and Exposed Dose of Gamma Radiation

Authors
 SUNG HO KIM  ;  JONG HWAN LEE  ;  HEON OH  ;  SE RA KIM  ;  CHA-SOO LEE  ;  SUNG KEE JO  ;  TAE-HWAN KIM  ;  YUN-SIL LEE 
Citation
 JOURNAL OF RADIATION RESEARCH, Vol.42(3) : 255-264, 2001 
Journal Title
 JOURNAL OF RADIATION RESEARCH 
ISSN
 0449-3060 
Issue Date
2001
MeSH
Abnormalities, Radiation-Induced/embryology ; Abnormalities, Radiation-Induced/etiology* ; Animals ; Embryo, Mammalian/radiation effects ; Female ; Gestational Age ; Mice ; Mice, Inbred ICR ; Pregnancy ; Radiation Dosage
Keywords
Dose relationship ; Gestational age ; Radiation ; Mice ; Abnormalities
Abstract
In order to evaluate the importance of gestational age and the dose-incidence relationship by gamma radiation, pregnant ICR mice at gestational days from 2.5 to 15.5 days post-coitus (p.c.) were exposed to a single dose of 2.0 Gy and also at day 11.5 after conception, which was the most sensitive stage for the induction of major congenital malformations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, changes in head size and other morphological abnormalities. The only demonstrable effect of irradiation during the pre-implantation period was an increase in prenatal mortality. Resorptions were maximal on exposure at day 2.5 after conception. The pre-implantation irradiated embryos which survived did not show any major fetal abnormalities. A small head, growth retardation, a cleft palate, dilatation of the cerebral ventricle, a renal pelvis, and abnormalities of the extremities and tail after exposure were prominent during the organogenesis period, especially on day 11.5 of gestation. As for the dose-incidence relationship, the incidence of a small head, growth-retarded fetuses, a cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose as the radiation dose increased. The result indicated that the late period of organogenesis in the development of the brain, skull and extremities of a mouse was a particularly sensitive phase. The threshold doses of radiation that induced a cleft palate and dilatation of the cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively.
Files in This Item:
T200101689.pdf Download
DOI
10.1269/jrr.42.255
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yun Sil(이윤실)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142149
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