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Dependence of Malformation upon Gestational Age and Exposed Dose of Gamma Radiation

DC Field Value Language
dc.contributor.author이윤실-
dc.date.accessioned2016-02-19T10:59:30Z-
dc.date.available2016-02-19T10:59:30Z-
dc.date.issued2001-
dc.identifier.issn0449-3060-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142149-
dc.description.abstractIn order to evaluate the importance of gestational age and the dose-incidence relationship by gamma radiation, pregnant ICR mice at gestational days from 2.5 to 15.5 days post-coitus (p.c.) were exposed to a single dose of 2.0 Gy and also at day 11.5 after conception, which was the most sensitive stage for the induction of major congenital malformations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, changes in head size and other morphological abnormalities. The only demonstrable effect of irradiation during the pre-implantation period was an increase in prenatal mortality. Resorptions were maximal on exposure at day 2.5 after conception. The pre-implantation irradiated embryos which survived did not show any major fetal abnormalities. A small head, growth retardation, a cleft palate, dilatation of the cerebral ventricle, a renal pelvis, and abnormalities of the extremities and tail after exposure were prominent during the organogenesis period, especially on day 11.5 of gestation. As for the dose-incidence relationship, the incidence of a small head, growth-retarded fetuses, a cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose as the radiation dose increased. The result indicated that the late period of organogenesis in the development of the brain, skull and extremities of a mouse was a particularly sensitive phase. The threshold doses of radiation that induced a cleft palate and dilatation of the cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively.-
dc.description.statementOfResponsibilityopen-
dc.format.extent255~264-
dc.relation.isPartOfJOURNAL OF RADIATION RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbnormalities, Radiation-Induced/embryology-
dc.subject.MESHAbnormalities, Radiation-Induced/etiology*-
dc.subject.MESHAnimals-
dc.subject.MESHEmbryo, Mammalian/radiation effects-
dc.subject.MESHFemale-
dc.subject.MESHGestational Age-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHPregnancy-
dc.subject.MESHRadiation Dosage-
dc.titleDependence of Malformation upon Gestational Age and Exposed Dose of Gamma Radiation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorSUNG HO KIM-
dc.contributor.googleauthorJONG HWAN LEE-
dc.contributor.googleauthorHEON OH-
dc.contributor.googleauthorSE RA KIM-
dc.contributor.googleauthorCHA-SOO LEE-
dc.contributor.googleauthorSUNG KEE JO-
dc.contributor.googleauthorTAE-HWAN KIM-
dc.contributor.googleauthorYUN-SIL LEE-
dc.identifier.doi10.1269/jrr.42.255-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03021-
dc.relation.journalcodeJ01727-
dc.identifier.eissn1349-9157-
dc.identifier.pmid11840642-
dc.subject.keywordDose relationship-
dc.subject.keywordGestational age-
dc.subject.keywordRadiation-
dc.subject.keywordMice-
dc.subject.keywordAbnormalities-
dc.contributor.alternativeNameLee, Yun Sil-
dc.contributor.affiliatedAuthorLee, Yun Sil-
dc.rights.accessRightsfree-
dc.citation.volume42-
dc.citation.number3-
dc.citation.startPage255-
dc.citation.endPage264-
dc.identifier.bibliographicCitationJOURNAL OF RADIATION RESEARCH, Vol.42(3) : 255-264, 2001-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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