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Role of Nitric Oxide and Mucus in Ischemia/Reperfusion-Induced Gastric Mucosal Injury in Rats

Authors
 Kim H.  ;  Hwan Kim K. 
Citation
 PHARMACOLOGY, Vol.62(4) : 200-207, 2001 
Journal Title
 PHARMACOLOGY 
ISSN
 0031-7012 
Issue Date
2001
MeSH
Animals ; Arginine/pharmacology ; Cyclic GMP/metabolism ; Gastric Mucosa/drug effects ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology* ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Lipid Peroxides/metabolism ; Male ; Mucus/metabolism* ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/physiology* ; Nitric Oxide Synthase/metabolism ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/physiopathology*
Keywords
Nitric oxide ; Mucus ; Gastric mucosa ; Ischemia/reperfusion
Abstract
The present study aims at investigating the role of nitric oxide (NO) on the oxidative damage in gastric mucosa of rats which received ischemia/reperfusion (I/R) and its relation to mucus. NO synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) were injected intraperitoneally to the rats 30 min prior to I/R which was induced by clamping the celiac artery and the superior mesenteric artery for 30 min and reperfusion for 1 h. As a result, I/R increased lipid peroxide production and decreased the contents of glutathione (GSH), cGMP and mucus as well as GSH peroxidase activities of gastric mucosa. I/R decreased the activity and protein of NO synthase (NOS) in gastric mucosa. Pretreatment of L-arginine, a substrate for NOS, prevented I/R-induced alterations of gastric mucosa. However, L-NAME, an NOS inhibitor, deteriorated oxidative damage induced by I/R. In conclusion, NO has an antioxidant defensive role on gastric mucosa by maintaining mucus, GSH and GSH peroxidase, which were related to preservation of cGMP and NOS in gastric mucosa.
Full Text
http://www.karger.com/Article/FullText/56095
DOI
10.1159/000056095
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141956
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