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Role of Nitric Oxide and Mucus in Ischemia/Reperfusion-Induced Gastric Mucosal Injury in Rats

DC FieldValueLanguage
dc.contributor.author김경환-
dc.date.accessioned2016-02-19T10:54:12Z-
dc.date.available2016-02-19T10:54:12Z-
dc.date.issued2001-
dc.identifier.issn0031-7012-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141956-
dc.description.abstractThe present study aims at investigating the role of nitric oxide (NO) on the oxidative damage in gastric mucosa of rats which received ischemia/reperfusion (I/R) and its relation to mucus. NO synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) were injected intraperitoneally to the rats 30 min prior to I/R which was induced by clamping the celiac artery and the superior mesenteric artery for 30 min and reperfusion for 1 h. As a result, I/R increased lipid peroxide production and decreased the contents of glutathione (GSH), cGMP and mucus as well as GSH peroxidase activities of gastric mucosa. I/R decreased the activity and protein of NO synthase (NOS) in gastric mucosa. Pretreatment of L-arginine, a substrate for NOS, prevented I/R-induced alterations of gastric mucosa. However, L-NAME, an NOS inhibitor, deteriorated oxidative damage induced by I/R. In conclusion, NO has an antioxidant defensive role on gastric mucosa by maintaining mucus, GSH and GSH peroxidase, which were related to preservation of cGMP and NOS in gastric mucosa.-
dc.description.statementOfResponsibilityopen-
dc.format.extent200~207-
dc.relation.isPartOfPHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHArginine/pharmacology-
dc.subject.MESHCyclic GMP/metabolism-
dc.subject.MESHGastric Mucosa/drug effects-
dc.subject.MESHGastric Mucosa/metabolism-
dc.subject.MESHGastric Mucosa/pathology*-
dc.subject.MESHGlutathione/metabolism-
dc.subject.MESHGlutathione Peroxidase/metabolism-
dc.subject.MESHLipid Peroxides/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMucus/metabolism*-
dc.subject.MESHNG-Nitroarginine Methyl Ester/pharmacology-
dc.subject.MESHNitric Oxide/physiology*-
dc.subject.MESHNitric Oxide Synthase/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReperfusion Injury/physiopathology*-
dc.titleRole of Nitric Oxide and Mucus in Ischemia/Reperfusion-Induced Gastric Mucosal Injury in Rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorKim H.-
dc.contributor.googleauthorHwan Kim K.-
dc.identifier.doi10.1159/000056095-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00311-
dc.relation.journalcodeJ02509-
dc.identifier.eissn1423-0313-
dc.identifier.pmid11359995-
dc.identifier.urlhttp://www.karger.com/Article/FullText/56095-
dc.subject.keywordNitric oxide-
dc.subject.keywordMucus-
dc.subject.keywordGastric mucosa-
dc.subject.keywordIschemia/reperfusion-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.affiliatedAuthorKim, Kyung Hwan-
dc.rights.accessRightsnot free-
dc.citation.volume62-
dc.citation.number4-
dc.citation.startPage200-
dc.citation.endPage207-
dc.identifier.bibliographicCitationPHARMACOLOGY, Vol.62(4) : 200-207, 2001-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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