Cited 37 times in
Role of Nitric Oxide and Mucus in Ischemia/Reperfusion-Induced Gastric Mucosal Injury in Rats
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2016-02-19T10:54:12Z | - |
dc.date.available | 2016-02-19T10:54:12Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0031-7012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141956 | - |
dc.description.abstract | The present study aims at investigating the role of nitric oxide (NO) on the oxidative damage in gastric mucosa of rats which received ischemia/reperfusion (I/R) and its relation to mucus. NO synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) were injected intraperitoneally to the rats 30 min prior to I/R which was induced by clamping the celiac artery and the superior mesenteric artery for 30 min and reperfusion for 1 h. As a result, I/R increased lipid peroxide production and decreased the contents of glutathione (GSH), cGMP and mucus as well as GSH peroxidase activities of gastric mucosa. I/R decreased the activity and protein of NO synthase (NOS) in gastric mucosa. Pretreatment of L-arginine, a substrate for NOS, prevented I/R-induced alterations of gastric mucosa. However, L-NAME, an NOS inhibitor, deteriorated oxidative damage induced by I/R. In conclusion, NO has an antioxidant defensive role on gastric mucosa by maintaining mucus, GSH and GSH peroxidase, which were related to preservation of cGMP and NOS in gastric mucosa. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 200~207 | - |
dc.relation.isPartOf | PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Arginine/pharmacology | - |
dc.subject.MESH | Cyclic GMP/metabolism | - |
dc.subject.MESH | Gastric Mucosa/drug effects | - |
dc.subject.MESH | Gastric Mucosa/metabolism | - |
dc.subject.MESH | Gastric Mucosa/pathology* | - |
dc.subject.MESH | Glutathione/metabolism | - |
dc.subject.MESH | Glutathione Peroxidase/metabolism | - |
dc.subject.MESH | Lipid Peroxides/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mucus/metabolism* | - |
dc.subject.MESH | NG-Nitroarginine Methyl Ester/pharmacology | - |
dc.subject.MESH | Nitric Oxide/physiology* | - |
dc.subject.MESH | Nitric Oxide Synthase/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reperfusion Injury/physiopathology* | - |
dc.title | Role of Nitric Oxide and Mucus in Ischemia/Reperfusion-Induced Gastric Mucosal Injury in Rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Kim H. | - |
dc.contributor.googleauthor | Hwan Kim K. | - |
dc.identifier.doi | 10.1159/000056095 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J02509 | - |
dc.identifier.eissn | 1423-0313 | - |
dc.identifier.pmid | 11359995 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/56095 | - |
dc.subject.keyword | Nitric oxide | - |
dc.subject.keyword | Mucus | - |
dc.subject.keyword | Gastric mucosa | - |
dc.subject.keyword | Ischemia/reperfusion | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 62 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 200 | - |
dc.citation.endPage | 207 | - |
dc.identifier.bibliographicCitation | PHARMACOLOGY, Vol.62(4) : 200-207, 2001 | - |
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