0 269

Cited 0 times in

Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

Authors
 Jeremy Ricci  ;  Dongguk Min  ;  Mankil Jung  ;  Kwang-Kyun Park  ;  Won-Yoon Chung  ;  Hyenchong Lim  ;  Miyeon Oh 
Citation
 Medicinal Chemistry, Vol.11(8) : 747-752, 2015 
Journal Title
 Medicinal Chemistry 
ISSN
 1573-4064 
Issue Date
2015
MeSH
Angiogenesis Inhibitors/chemical synthesis* ; Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology* ; Animals ; Chick Embryo ; Chickens ; Chorioallantoic Membrane/drug effects* ; Dose-Response Relationship, Drug ; Fatty Acids/chemical synthesis* ; Fatty Acids/chemistry ; Fatty Acids/pharmacology* ; Molecular Structure ; Pheromones/chemical synthesis* ; Pheromones/chemistry ; Pheromones/pharmacology* ; Structure-Activity Relationship
Keywords
Daumone ; glycolipid ; antiangiogenic activity ; synthesis
Abstract
Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.
Full Text
http://www.eurekaselect.com/131268/article
DOI
10.2174/1573406411666150514100630#sthash.Mj2rBjsT.dpuf
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141840
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse