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Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

Authors
 Jeremy Ricci ; Dongguk Min ; Mankil Jung ; Kwang-Kyun Park ; Won-Yoon Chung ; Hyenchong Lim ; Miyeon Oh 
Citation
 Medicinal Chemistry, Vol.11(8) : 747~752, 2015 
Journal Title
 Medicinal Chemistry 
ISSN
 1573-4064 
Issue Date
2015
Abstract
Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141840
DOI
10.2174/1573406411666150514100630#sthash.Mj2rBjsT.dpuf
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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Link
 http://www.eurekaselect.com/131268/article
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