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Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

DC Field Value Language
dc.contributor.author박광균-
dc.contributor.author정원윤-
dc.date.accessioned2016-02-04T12:04:39Z-
dc.date.available2016-02-04T12:04:39Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141840-
dc.description.abstractDaumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfMEDICINAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAngiogenesis Inhibitors/chemical synthesis*-
dc.subject.MESHAngiogenesis Inhibitors/chemistry-
dc.subject.MESHAngiogenesis Inhibitors/pharmacology*-
dc.subject.MESHAnimals-
dc.subject.MESHChick Embryo-
dc.subject.MESHChickens-
dc.subject.MESHChorioallantoic Membrane/drug effects*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHFatty Acids/chemical synthesis*-
dc.subject.MESHFatty Acids/chemistry-
dc.subject.MESHFatty Acids/pharmacology*-
dc.subject.MESHMolecular Structure-
dc.subject.MESHPheromones/chemical synthesis*-
dc.subject.MESHPheromones/chemistry-
dc.subject.MESHPheromones/pharmacology*-
dc.subject.MESHStructure-Activity Relationship-
dc.titleSynthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorJeremy Ricci-
dc.contributor.googleauthorDongguk Min-
dc.contributor.googleauthorMankil Jung-
dc.contributor.googleauthorKwang-Kyun Park-
dc.contributor.googleauthorWon-Yoon Chung-
dc.contributor.googleauthorHyenchong Lim-
dc.contributor.googleauthorMiyeon Oh-
dc.identifier.doi10.2174/1573406411666150514100630-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01429-
dc.contributor.localIdA03676-
dc.relation.journalcodeJ02212-
dc.identifier.eissn2161-0444-
dc.identifier.pmid25974079-
dc.identifier.urlhttp://www.eurekaselect.com/131268/article-
dc.subject.keywordDaumone-
dc.subject.keywordglycolipid-
dc.subject.keywordantiangiogenic activity-
dc.subject.keywordsynthesis-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.alternativeNameChung, Won Yoon-
dc.contributor.affiliatedAuthorPark, Kwang Kyun-
dc.contributor.affiliatedAuthorChung, Won Yoon-
dc.rights.accessRightsnot free-
dc.citation.volume11-
dc.citation.number8-
dc.citation.startPage747-
dc.citation.endPage752-
dc.identifier.bibliographicCitationMEDICINAL CHEMISTRY, Vol.11(8) : 747-752, 2015-
dc.identifier.rimsid30913-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
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