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Visceral adiposity is associated with altered myocardial glucose uptake measured by (18)FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes

 Gyuri Kim  ;  Kwanhyeong Jo  ;  Mijin Yun  ;  Eun Seok Kang  ;  Hye Jin Wang  ;  Hye‑jin Yoon  ;  Eugene Han  ;  Yong‑ho Lee  ;  Kwang Joon Kim 
Journal Title
Issue Date
Adult ; Aged ; Diabetes Mellitus, Type 2/diagnostic imaging ; Diabetes Mellitus, Type 2/metabolism* ; Female ; Fluorodeoxyglucose F18 ; Glucose/metabolism* ; Heart/diagnostic imaging* ; Humans ; Intra-Abdominal Fat/diagnostic imaging* ; Male ; Middle Aged ; Myocardium/metabolism* ; Obesity, Abdominal/diagnostic imaging ; Obesity, Abdominal/metabolism* ; Positron-Emission Tomography ; Prediabetic State/diagnostic imaging ; Prediabetic State/metabolism* ; Radiopharmaceuticals ; Subcutaneous Fat/diagnostic imaging* ; Tomography, X-Ray Computed
Visceral fat ; Myocardium ; Type 2 diabetes mellitus ; Positron emission tomography ; Insulin resistance
BACKGROUND: The heart requires constant sources of energy mostly from free fatty acids (FFA) and glucose. The alteration in myocardial substrate metabolism occurs in the heart of diabetic patients, but its specific association with other metabolic variables remains unclear. We aimed to evaluate glucose uptake in hearts of subjects with normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) using [(18)F]-fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) in association with visceral and subcutaneous adiposity, and metabolic laboratory parameters. METHODS: A total of 346 individuals (NGT, n = 76; prediabetes, n = 208; T2DM, n = 62) in a health promotion center of a tertiary hospital were enrolled. The fasting myocardial glucose uptake, and visceral and subcutaneous fat areas were evaluated using (18)FDG-PET and abdominal computed tomography, respectively. RESULTS: Myocardial glucose uptake was significantly decreased in subjects with T2DM compared to the NGT or prediabetes groups (p for trend = 0.001). Multivariate linear regression analyses revealed that visceral fat area (β = -0.22, p = 0.018), fasting FFA (β = -0.39, p < 0.001), and uric acid levels (β = -0.21, p = 0.007) were independent determinants of myocardial glucose uptake. Multiple logistic analyses demonstrated that decreased myocardial glucose uptake (OR 2.32; 95 % CI 1.02-5.29, p = 0.045) and visceral fat area (OR 1.02, 95 % CI 1.01-1.03, p = 0.018) were associated with T2DM. CONCLUSIONS: Our findings indicate visceral adiposity is strongly associated with the alteration of myocardial glucose uptake evaluated by (18)FDG-PET, and its association further relates to T2DM.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Gyuri(김규리)
Wang, Hye Jin(왕혜진)
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Yoon, Hye Jin(윤혜진)
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Han, Eu Gene(한유진)
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