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Cited 11 times in

Visceral adiposity is associated with altered myocardial glucose uptake measured by (18)FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김규리-
dc.contributor.author왕혜진-
dc.contributor.author윤미진-
dc.contributor.author윤혜진-
dc.contributor.author이용호-
dc.contributor.author한유진-
dc.contributor.author김광준-
dc.date.accessioned2016-02-04T12:03:45Z-
dc.date.available2016-02-04T12:03:45Z-
dc.date.issued2015-
dc.identifier.issn1475-2840-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141806-
dc.description.abstractBACKGROUND: The heart requires constant sources of energy mostly from free fatty acids (FFA) and glucose. The alteration in myocardial substrate metabolism occurs in the heart of diabetic patients, but its specific association with other metabolic variables remains unclear. We aimed to evaluate glucose uptake in hearts of subjects with normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) using [(18)F]-fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) in association with visceral and subcutaneous adiposity, and metabolic laboratory parameters. METHODS: A total of 346 individuals (NGT, n = 76; prediabetes, n = 208; T2DM, n = 62) in a health promotion center of a tertiary hospital were enrolled. The fasting myocardial glucose uptake, and visceral and subcutaneous fat areas were evaluated using (18)FDG-PET and abdominal computed tomography, respectively. RESULTS: Myocardial glucose uptake was significantly decreased in subjects with T2DM compared to the NGT or prediabetes groups (p for trend = 0.001). Multivariate linear regression analyses revealed that visceral fat area (β = -0.22, p = 0.018), fasting FFA (β = -0.39, p < 0.001), and uric acid levels (β = -0.21, p = 0.007) were independent determinants of myocardial glucose uptake. Multiple logistic analyses demonstrated that decreased myocardial glucose uptake (OR 2.32; 95 % CI 1.02-5.29, p = 0.045) and visceral fat area (OR 1.02, 95 % CI 1.01-1.03, p = 0.018) were associated with T2DM. CONCLUSIONS: Our findings indicate visceral adiposity is strongly associated with the alteration of myocardial glucose uptake evaluated by (18)FDG-PET, and its association further relates to T2DM.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfCardiovascular Diabetology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHDiabetes Mellitus, Type 2/diagnostic imaging-
dc.subject.MESHDiabetes Mellitus, Type 2/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHGlucose/metabolism*-
dc.subject.MESHHeart/diagnostic imaging*-
dc.subject.MESHHumans-
dc.subject.MESHIntra-Abdominal Fat/diagnostic imaging*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardium/metabolism*-
dc.subject.MESHObesity, Abdominal/diagnostic imaging-
dc.subject.MESHObesity, Abdominal/metabolism*-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHPrediabetic State/diagnostic imaging-
dc.subject.MESHPrediabetic State/metabolism*-
dc.subject.MESHRadiopharmaceuticals-
dc.subject.MESHSubcutaneous Fat/diagnostic imaging*-
dc.subject.MESHTomography, X-Ray Computed-
dc.titleVisceral adiposity is associated with altered myocardial glucose uptake measured by (18)FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorGyuri Kim-
dc.contributor.googleauthorKwanhyeong Jo-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorHye Jin Wang-
dc.contributor.googleauthorHye‑jin Yoon-
dc.contributor.googleauthorEugene Han-
dc.contributor.googleauthorYong‑ho Lee-
dc.contributor.googleauthorKwang Joon Kim-
dc.identifier.doi10.1186/s12933-015-0310-4-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00068-
dc.contributor.localIdA00322-
dc.contributor.localIdA02422-
dc.contributor.localIdA02550-
dc.contributor.localIdA02624-
dc.contributor.localIdA02989-
dc.contributor.localIdA04311-
dc.contributor.localIdA00317-
dc.relation.journalcodeJ00460-
dc.identifier.pmid26538247-
dc.subject.keywordVisceral fat-
dc.subject.keywordMyocardium-
dc.subject.keywordType 2 diabetes mellitus-
dc.subject.keywordPositron emission tomography-
dc.subject.keywordInsulin resistance-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Gyuri-
dc.contributor.alternativeNameWang, Hye Jin-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.alternativeNameYoon, Hye Jin-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameHan, Eu Gene-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, Gyuri-
dc.contributor.affiliatedAuthorWang, Hye Jin-
dc.contributor.affiliatedAuthorYun, Mi Jin-
dc.contributor.affiliatedAuthorYoon, Hye Jin-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorHan, Eu Gene-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.rights.accessRightsfree-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage148-
dc.identifier.bibliographicCitationCardiovascular Diabetology, Vol.14(1) : 148, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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