Cited 31 times in
Visceral adiposity is associated with altered myocardial glucose uptake measured by (18)FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 김규리 | - |
dc.contributor.author | 왕혜진 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 윤혜진 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 한유진 | - |
dc.contributor.author | 김광준 | - |
dc.date.accessioned | 2016-02-04T12:03:45Z | - |
dc.date.available | 2016-02-04T12:03:45Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141806 | - |
dc.description.abstract | BACKGROUND: The heart requires constant sources of energy mostly from free fatty acids (FFA) and glucose. The alteration in myocardial substrate metabolism occurs in the heart of diabetic patients, but its specific association with other metabolic variables remains unclear. We aimed to evaluate glucose uptake in hearts of subjects with normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) using [(18)F]-fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) in association with visceral and subcutaneous adiposity, and metabolic laboratory parameters. METHODS: A total of 346 individuals (NGT, n = 76; prediabetes, n = 208; T2DM, n = 62) in a health promotion center of a tertiary hospital were enrolled. The fasting myocardial glucose uptake, and visceral and subcutaneous fat areas were evaluated using (18)FDG-PET and abdominal computed tomography, respectively. RESULTS: Myocardial glucose uptake was significantly decreased in subjects with T2DM compared to the NGT or prediabetes groups (p for trend = 0.001). Multivariate linear regression analyses revealed that visceral fat area (β = -0.22, p = 0.018), fasting FFA (β = -0.39, p < 0.001), and uric acid levels (β = -0.21, p = 0.007) were independent determinants of myocardial glucose uptake. Multiple logistic analyses demonstrated that decreased myocardial glucose uptake (OR 2.32; 95 % CI 1.02-5.29, p = 0.045) and visceral fat area (OR 1.02, 95 % CI 1.01-1.03, p = 0.018) were associated with T2DM. CONCLUSIONS: Our findings indicate visceral adiposity is strongly associated with the alteration of myocardial glucose uptake evaluated by (18)FDG-PET, and its association further relates to T2DM. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/diagnostic imaging | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18 | - |
dc.subject.MESH | Glucose/metabolism* | - |
dc.subject.MESH | Heart/diagnostic imaging* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intra-Abdominal Fat/diagnostic imaging* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardium/metabolism* | - |
dc.subject.MESH | Obesity, Abdominal/diagnostic imaging | - |
dc.subject.MESH | Obesity, Abdominal/metabolism* | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Prediabetic State/diagnostic imaging | - |
dc.subject.MESH | Prediabetic State/metabolism* | - |
dc.subject.MESH | Radiopharmaceuticals | - |
dc.subject.MESH | Subcutaneous Fat/diagnostic imaging* | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Visceral adiposity is associated with altered myocardial glucose uptake measured by (18)FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Gyuri Kim | - |
dc.contributor.googleauthor | Kwanhyeong Jo | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Hye Jin Wang | - |
dc.contributor.googleauthor | Hye‑jin Yoon | - |
dc.contributor.googleauthor | Eugene Han | - |
dc.contributor.googleauthor | Yong‑ho Lee | - |
dc.contributor.googleauthor | Kwang Joon Kim | - |
dc.identifier.doi | 10.1186/s12933-015-0310-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00322 | - |
dc.contributor.localId | A02422 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A02624 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A04311 | - |
dc.contributor.localId | A00317 | - |
dc.relation.journalcode | J00460 | - |
dc.identifier.eissn | 1475-2840 | - |
dc.identifier.pmid | 26538247 | - |
dc.subject.keyword | Visceral fat | - |
dc.subject.keyword | Myocardium | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.subject.keyword | Positron emission tomography | - |
dc.subject.keyword | Insulin resistance | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Gyuri | - |
dc.contributor.alternativeName | Wang, Hye Jin | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Yoon, Hye Jin | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.alternativeName | Han, Eu Gene | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Gyuri | - |
dc.contributor.affiliatedAuthor | Wang, Hye Jin | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Yoon, Hye Jin | - |
dc.contributor.affiliatedAuthor | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | Han, Eu Gene | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 148 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, Vol.14(1) : 148, 2015 | - |
dc.identifier.rimsid | 30902 | - |
dc.type.rims | ART | - |
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