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An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a propensity-matched analysis

 Sang Hoon Oh  ;  Joo Suk Oh  ;  Young-Min Kim  ;  Kyu Nam Park  ;  Seung Pill Choi  ;  Gi Woon Kim  ;  Kyung Woon Jeung  ;  Tae Chang Jang  ;  Yoo Seok Park  ;  Yeon Young Kyong 
 CRITICAL CARE, Vol.19 : 85, 2015 
Journal Title
Issue Date
Adult ; Aged ; Cardiopulmonary Resuscitation/methods* ; Female ; Heart Arrest/mortality ; Heart Arrest/therapy* ; Hospital Mortality ; Humans ; Hypothermia, Induced/adverse effects ; Hypothermia, Induced/methods* ; Male ; Middle Aged ; Propensity Score ; Registries ; Republic of Korea ; Retrospective Studies ; Rewarming/adverse effects ; Treatment Outcome
Propensity Score ; Propensity Score Match ; Therapeutic Hypothermia ; Surface Cool ; Cerebral Performance Category
INTRODUCTION: Various methods and devices have been described for cooling after cardiac arrest, but the ideal cooling method remains unclear. The aim of this study was to compare the neurological outcomes, efficacies and adverse events of surface and endovascular cooling techniques in cardiac arrest patients. METHODS: We performed a multicenter, retrospective, registry-based study of adult cardiac arrest patients treated with therapeutic hypothermia presenting to 24 hospitals across South Korea from 2007 to 2012. We included patients who received therapeutic hypothermia using overall surface or endovascular cooling devices and compared the neurological outcomes, efficacies and adverse events of both cooling techniques. To adjust for differences in the baseline characteristics of each cooling method, we performed one-to-one matching by the propensity score. RESULTS: In total, 803 patients were included in the analysis. Of these patients, 559 underwent surface cooling, and the remaining 244 patients underwent endovascular cooling. In the unmatched cohort, a greater number of adverse events occurred in the surface cooling group. Surface cooling was significantly associated with a poor neurological outcome (cerebral performance category 3-5) at hospital discharge (p = 0.01). After propensity score matching, surface cooling was not associated with poor neurological outcome and hospital mortality [odds ratio (OR): 1.26, 95% confidence interval (CI): 0.81-1.96, p = 0.31 and OR: 0.85, 95% CI: 0.55-1.30, p = 0.44, respectively]. Although surface cooling was associated with an increased incidence of adverse events (such as overcooling, rebound hyperthermia, rewarming related hypoglycemia and hypotension) compared with endovascular cooling, these complications were not associated with surface cooling using hydrogel pads. CONCLUSIONS: In the overall matched cohort, no significant difference in neurological outcomes and hospital morality was observed between the surface and endovascular cooling methods.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Park, Yoo Seok(박유석) ORCID logo https://orcid.org/0000-0003-1543-4664
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