184 155

Cited 6 times in

Rapid bone regeneration by Escherichia coli-derived recombinant human bone morphogenetic protein-2 loaded on a hydroxyapatite carrier in the rabbit calvarial defect model

 Chung-Hoon Chung  ;  You-Kyoung Kim  ;  Jung-Seok Lee  ;  Ui-Won Jung  ;  Eun-Kyoung Pang  ;  Seong-Ho Choi 
 Biomaterials Research, Vol.19 : 17-17, 2015 
Journal Title
 Biomaterials Research 
Issue Date
BACKGROUND: The aim of this study was to determine the osteoconductivity of hydroxyapatite particles (HAP) as a carrier for Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2). Two 8-mm diameter bicortical calvarial defects were created in each of 20 rabbits. One of each pair of defects was randomly assigned to be filled with HAP only (HAP group) or ErhBMP-2 loaded HAP (ErhBMP-2/HAP group), while the other defect was left untreated (control group). The animals were killed after either 2 weeks (n = 10) or 8 weeks (n = 10) of healing, and histological, histomorphometric, and tomographic analyses were performed. RESULTS: All experimental sites showed uneventful healing during the postoperative healing period. In both histomorphometric and tomographic analyses, the new bone area or volume of the ErhBMP-2/HAP group was significantly greater than that of the HAP and control groups at 2 weeks (p < 0.05). However, at 8 weeks, no significant difference in new bone area or volume was observed between the ErhBMP-2/HAP and HAP groups. The total augmented area or volume was not significantly different between the ErhBMP-2/HAP and HAP groups at 2 and 8 weeks. CONCLUSIONS: Combining ErhBMP-2 with HAP could significantly promote rapid initial new bone formation. Moreover, HAP graft could increase new bone formation and space maintenance, therefore it might be one of the effective carriers of ErhBMP-2.
Files in This Item:
T201504349.pdf Download
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
이중석(Lee, Jung Seok) ORCID logo https://orcid.org/0000-0003-1276-5978
정의원(Jung, Ui Won) ORCID logo https://orcid.org/0000-0001-6371-4172
최성호(Choi, Seong Ho) ORCID logo https://orcid.org/0000-0001-6704-6124
RIS (EndNote)
XLS (Excel)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.