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수산화인회석 캐리어에 코팅된 골형성단백 2형이 토끼 두개골 골재생 모델에서 인접한 조직에 미치는 영향

Other Titles
 Influence of BMP-2-loaded hydroxyapatite carrier on a neighboring ectopic site in the rabbit calvarial defect model 
Authors
 이재홍  ;  정정훈  ;  김유경  ;  이중석  ;  김영택  ;  방은경  ;  최성호 
Citation
 Journal of Korean Academy of Osseointegration (대한인공치아골유착학회지), Vol.7(1) : 5-11, 2015 
Journal Title
 Journal of Korean Academy of Osseointegration (대한인공치아골유착학회지) 
Issue Date
2015
Keywords
Bone graft ; Bone morphogenetic protein-2 ; Bone regeneration
Abstract
The aim of this study was to elucidate the influence of bone morphogenetic protein-2 (BMP-2)-loaded hydroxyapatite (HA) carrier on a neighboring surgical defect in the rabbit calvarial defect model. Two circular bicortical defects (8 mm in diameter) were created 2 mm apart on each rabbit calvarium (n=10 animals in each group). The rabbits were randomly divided into two groups: BMP-2-loaded HA and HA only. Control defects were designated as HAC (the sham surgical site located at the neighboring defect filled with HA only) and HAB (the sham surgical site located at the neighboring defect filled with BMP-2-loaded HA). Twenty animals were sacrificed at 2 and 8weeks postsurgery, and microcomputed tomographic, histologic, and histomorphometric evaluations were performed. The HAC and HAB groups showed small amounts of new bone formation at both healing periods. Radiographic, histologic, and histomorphometric features such as defect closure, new bone area, total augmented area, total bone/new bone volume, and closure volume did not differ significantly between the two groups. When evaluating the influence of BMP-2-loaded HA on a neighboring sham surgical site, inadvertent BMP-2 expression will not occur when the circular defects are separated by at least 2 mm.
Files in This Item:
T201504205.pdf Download
DOI
2015
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jae Hong(이재홍)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141733
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