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Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome

 Yonggeun Cho  ;  Sang-Guk Lee  ;  Sun Ha Jee  ;  Jeong-Ho Kim 
 ANNALS OF LABORATORY MEDICINE, Vol.35(6) : 586-594, 2015 
Journal Title
Issue Date
Adult ; Case-Control Studies ; Cholesterol, LDL/blood* ; Cohort Studies ; Female ; Humans ; Hypertriglyceridemia/complications* ; Hypertriglyceridemia/diagnosis ; Linear Models ; Male ; Metabolic Syndrome/complications* ; Metabolic Syndrome/diagnosis ; Middle Aged ; Risk Factors ; Triglycerides/blood
Hypertriglyceridemia ; Metabolic syndrome ; Small dense LDL
BACKGROUND: We aimed to determine the major contributing component of metabolic syndrome (MetS) that results in an elevated small dense LDL cholesterol (sdLDL-C) concentration and sdLDL-C/LDL-C ratio. METHODS: Four hundred and forty-seven subjects (225 men; 222 women) with MetS were randomly selected from the Korean Metabolic Syndrome Research Initiatives-Seoul cohort study. Age- and sex-matched healthy controls (181 men; 179 women) were also randomly selected from the same cohort. RESULTS: A comparison of the median values of the sdLDL-C concentration between subgroups, divided according to whether subjects met or did not meet the criteria for each MetS component in patients with MetS, revealed a significant difference in the sdLDL-C concentration only between subgroups divided according to whether subjects met or did not meet the triglyceride (TG) criteria (P<0.05 for each gender). The TG level showed a good correlation with sdLDL-C concentration (correlation coefficients [r]=0.543 for men; 0.653 for women) and the sdLDL-C/LDL-C ratio (r=0.789 for men; 0.745 for women). Multiple linear regression analyses conducted for the MetS group concordantly identified TG as one of the most significant contributors to sdLDL-C concentration (β=0.1747±0.0105, P<0.0001) and the sdLDL-C/LDL-C ratio (β=6.9518±0.3011, P<0.0001). CONCLUSIONS: Among five MetS components, only the abnormal TG level was a differentiating factor for sdLDL-C concentration and sdLDL-C/LDL-C ratio. These results were reproducible in both genders, with or without MetS.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Cho, Yonggeun(조용근) ORCID logo https://orcid.org/0000-0003-1946-4318
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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