Cited 28 times in
Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정호 | - |
dc.contributor.author | 이상국 | - |
dc.contributor.author | 조용근 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2016-02-04T12:00:35Z | - |
dc.date.available | 2016-02-04T12:00:35Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141690 | - |
dc.description.abstract | BACKGROUND: We aimed to determine the major contributing component of metabolic syndrome (MetS) that results in an elevated small dense LDL cholesterol (sdLDL-C) concentration and sdLDL-C/LDL-C ratio. METHODS: Four hundred and forty-seven subjects (225 men; 222 women) with MetS were randomly selected from the Korean Metabolic Syndrome Research Initiatives-Seoul cohort study. Age- and sex-matched healthy controls (181 men; 179 women) were also randomly selected from the same cohort. RESULTS: A comparison of the median values of the sdLDL-C concentration between subgroups, divided according to whether subjects met or did not meet the criteria for each MetS component in patients with MetS, revealed a significant difference in the sdLDL-C concentration only between subgroups divided according to whether subjects met or did not meet the triglyceride (TG) criteria (P<0.05 for each gender). The TG level showed a good correlation with sdLDL-C concentration (correlation coefficients [r]=0.543 for men; 0.653 for women) and the sdLDL-C/LDL-C ratio (r=0.789 for men; 0.745 for women). Multiple linear regression analyses conducted for the MetS group concordantly identified TG as one of the most significant contributors to sdLDL-C concentration (β=0.1747±0.0105, P<0.0001) and the sdLDL-C/LDL-C ratio (β=6.9518±0.3011, P<0.0001). CONCLUSIONS: Among five MetS components, only the abnormal TG level was a differentiating factor for sdLDL-C concentration and sdLDL-C/LDL-C ratio. These results were reproducible in both genders, with or without MetS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 586~594 | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cholesterol, LDL/blood* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertriglyceridemia/complications* | - |
dc.subject.MESH | Hypertriglyceridemia/diagnosis | - |
dc.subject.MESH | Linear Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Syndrome/complications* | - |
dc.subject.MESH | Metabolic Syndrome/diagnosis | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.title | Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yonggeun Cho | - |
dc.contributor.googleauthor | Sang-Guk Lee | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Jeong-Ho Kim | - |
dc.identifier.doi | 10.3343/alm.2015.35.6.586 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00903 | - |
dc.contributor.localId | A02810 | - |
dc.contributor.localId | A03864 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.identifier.pmid | 26354346 | - |
dc.subject.keyword | Hypertriglyceridemia | - |
dc.subject.keyword | Metabolic syndrome | - |
dc.subject.keyword | Small dense LDL | - |
dc.contributor.alternativeName | Kim, Jeong Ho | - |
dc.contributor.alternativeName | Lee, Sang Guk | - |
dc.contributor.alternativeName | Cho, Yong Geun | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Sang Guk | - |
dc.contributor.affiliatedAuthor | Cho, Yong Geun | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 586 | - |
dc.citation.endPage | 594 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.35(6) : 586-594, 2015 | - |
dc.identifier.rimsid | 30817 | - |
dc.type.rims | ART | - |
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