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Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome

DC FieldValueLanguage
dc.contributor.author김정호-
dc.contributor.author이상국-
dc.contributor.author조용근-
dc.contributor.author지선하-
dc.date.accessioned2016-02-04T12:00:35Z-
dc.date.available2016-02-04T12:00:35Z-
dc.date.issued2015-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141690-
dc.description.abstractBACKGROUND: We aimed to determine the major contributing component of metabolic syndrome (MetS) that results in an elevated small dense LDL cholesterol (sdLDL-C) concentration and sdLDL-C/LDL-C ratio. METHODS: Four hundred and forty-seven subjects (225 men; 222 women) with MetS were randomly selected from the Korean Metabolic Syndrome Research Initiatives-Seoul cohort study. Age- and sex-matched healthy controls (181 men; 179 women) were also randomly selected from the same cohort. RESULTS: A comparison of the median values of the sdLDL-C concentration between subgroups, divided according to whether subjects met or did not meet the criteria for each MetS component in patients with MetS, revealed a significant difference in the sdLDL-C concentration only between subgroups divided according to whether subjects met or did not meet the triglyceride (TG) criteria (P<0.05 for each gender). The TG level showed a good correlation with sdLDL-C concentration (correlation coefficients [r]=0.543 for men; 0.653 for women) and the sdLDL-C/LDL-C ratio (r=0.789 for men; 0.745 for women). Multiple linear regression analyses conducted for the MetS group concordantly identified TG as one of the most significant contributors to sdLDL-C concentration (β=0.1747±0.0105, P<0.0001) and the sdLDL-C/LDL-C ratio (β=6.9518±0.3011, P<0.0001). CONCLUSIONS: Among five MetS components, only the abnormal TG level was a differentiating factor for sdLDL-C concentration and sdLDL-C/LDL-C ratio. These results were reproducible in both genders, with or without MetS.-
dc.description.statementOfResponsibilityopen-
dc.format.extent586~594-
dc.relation.isPartOfAnnals of Laboratory Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCholesterol, LDL/blood*-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypertriglyceridemia/complications*-
dc.subject.MESHHypertriglyceridemia/diagnosis-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/complications*-
dc.subject.MESHMetabolic Syndrome/diagnosis-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRisk Factors-
dc.subject.MESHTriglycerides/blood-
dc.titleHypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorYonggeun Cho-
dc.contributor.googleauthorSang-Guk Lee-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorJeong-Ho Kim-
dc.identifier.doi10.3343/alm.2015.35.6.586-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00903-
dc.contributor.localIdA02810-
dc.contributor.localIdA03864-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00164-
dc.identifier.pmid26354346-
dc.subject.keywordHypertriglyceridemia-
dc.subject.keywordMetabolic syndrome-
dc.subject.keywordSmall dense LDL-
dc.contributor.alternativeNameKim, Jeong Ho-
dc.contributor.alternativeNameLee, Sang Guk-
dc.contributor.alternativeNameCho, Yong Geun-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorKim, Jeong Ho-
dc.contributor.affiliatedAuthorLee, Sang Guk-
dc.contributor.affiliatedAuthorCho, Yong Geun-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsfree-
dc.citation.volume35-
dc.citation.number6-
dc.citation.startPage586-
dc.citation.endPage594-
dc.identifier.bibliographicCitationAnnals of Laboratory Medicine, Vol.35(6) : 586-594, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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