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Longitudinal FDG microPET imaging of neuropathic pain: does cerebellar activity correlate with neuropathic pain development in a rat model?

Authors
 Jinhyung Kim  ;  Jaewoo Shin  ;  Jin-Hwan Oh  ;  Hyun Ho Jung  ;  Young-Bo Kim  ;  Zang-Hee Cho  ;  Jin Woo Chang 
Citation
 ACTA NEUROCHIRURGICA, Vol.157(6) : 1051-1057, 2015 
Journal Title
 ACTA NEUROCHIRURGICA 
ISSN
 0001-6268 
Issue Date
2015
MeSH
Animals ; Cerebellum/diagnostic imaging ; Cerebellum/physiopathology* ; Fluorodeoxyglucose F18 ; Longitudinal Studies ; Male ; Neuralgia/diagnostic imaging ; Neuralgia/etiology ; Neuralgia/physiopathology* ; Pain Measurement/methods ; Peripheral Nerve Injuries/complications ; Peripheral Nerve Injuries/diagnostic imaging ; Peripheral Nerve Injuries/physiopathology* ; Radionuclide Imaging ; Rats ; Rats, Sprague-Dawley ; Sural Nerve/injuries ; Tibial Nerve/injuries
Keywords
Neuropathic pain ; microPET ; FDG ; Cerebellum ; Neuromodulation
Abstract
BACKGROUND: We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. METHODS: Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1 week before operation and then weekly for 8 weeks post-operation. RESULTS: The behavioral test was performed immediately after the every FDG administration. After TST modeling, neuropathic pain rats showed increased mechanical sensitivity of the injured hind paw. The withdrawal response to mechanical pain stimulation by von Frey filaments was observed within the first week (3.8 ± 0.73), and it rapidly increased in the third week (7.13 ± 0.82). This response reached a peak in the fourth week after surgery (9.0 ± 0.53), which persisted until the eighth week. In microPET scan imaging, cerebellum, which initially started from the ansiform lobule, was activated gradually to all part from the third week in all image acquisitions through the eighth week. CONCLUSIONS: The longitudinal microPET scan study of brains from neuropathic pain rat models showed sequential cerebellar activity that was in accordance with results from behavioral test responses, thus supporting a role for the cerebellum in the development of neuropathic pain.
Full Text
http://link.springer.com/article/10.1007%2Fs00701-015-2415-7
DOI
10.1007/s00701-015-2415-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Jin Hyung(김진형)
Shin, Jaewoo(신재우) ORCID logo https://orcid.org/0000-0002-6335-1292
Oh, Jin Hwan(오진환)
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Hyun Ho(정현호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141657
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