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Longitudinal FDG microPET imaging of neuropathic pain: does cerebellar activity correlate with neuropathic pain development in a rat model?

DC FieldValueLanguage
dc.contributor.author김진형-
dc.contributor.author신재우-
dc.contributor.author오진환-
dc.contributor.author장진우-
dc.contributor.author정현호-
dc.date.accessioned2016-02-04T11:59:43Z-
dc.date.available2016-02-04T11:59:43Z-
dc.date.issued2015-
dc.identifier.issn0001-6268-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141657-
dc.description.abstractBACKGROUND: We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. METHODS: Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1 week before operation and then weekly for 8 weeks post-operation. RESULTS: The behavioral test was performed immediately after the every FDG administration. After TST modeling, neuropathic pain rats showed increased mechanical sensitivity of the injured hind paw. The withdrawal response to mechanical pain stimulation by von Frey filaments was observed within the first week (3.8 ± 0.73), and it rapidly increased in the third week (7.13 ± 0.82). This response reached a peak in the fourth week after surgery (9.0 ± 0.53), which persisted until the eighth week. In microPET scan imaging, cerebellum, which initially started from the ansiform lobule, was activated gradually to all part from the third week in all image acquisitions through the eighth week. CONCLUSIONS: The longitudinal microPET scan study of brains from neuropathic pain rat models showed sequential cerebellar activity that was in accordance with results from behavioral test responses, thus supporting a role for the cerebellum in the development of neuropathic pain.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1051~1057-
dc.relation.isPartOfActa Neurochirurgica-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCerebellum/diagnostic imaging-
dc.subject.MESHCerebellum/physiopathology*-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHNeuralgia/diagnostic imaging-
dc.subject.MESHNeuralgia/etiology-
dc.subject.MESHNeuralgia/physiopathology*-
dc.subject.MESHPain Measurement/methods-
dc.subject.MESHPeripheral Nerve Injuries/complications-
dc.subject.MESHPeripheral Nerve Injuries/diagnostic imaging-
dc.subject.MESHPeripheral Nerve Injuries/physiopathology*-
dc.subject.MESHRadionuclide Imaging-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSural Nerve/injuries-
dc.subject.MESHTibial Nerve/injuries-
dc.titleLongitudinal FDG microPET imaging of neuropathic pain: does cerebellar activity correlate with neuropathic pain development in a rat model?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorJinhyung Kim-
dc.contributor.googleauthorJaewoo Shin-
dc.contributor.googleauthorJin-Hwan Oh-
dc.contributor.googleauthorHyun Ho Jung-
dc.contributor.googleauthorYoung-Bo Kim-
dc.contributor.googleauthorZang-Hee Cho-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.1007/s00701-015-2415-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02141-
dc.contributor.localIdA02403-
dc.contributor.localIdA03484-
dc.contributor.localIdA03775-
dc.contributor.localIdA01031-
dc.relation.journalcodeJ00018-
dc.identifier.pmid25916400-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00701-015-2415-7-
dc.subject.keywordNeuropathic pain-
dc.subject.keywordmicroPET-
dc.subject.keywordFDG-
dc.subject.keywordCerebellum-
dc.subject.keywordNeuromodulation-
dc.contributor.alternativeNameKim, Jin Hyung-
dc.contributor.alternativeNameShin, Jae Woo-
dc.contributor.alternativeNameOh, Jin Hwan-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.alternativeNameJung, Hyun Ho-
dc.contributor.affiliatedAuthorShin, Jae Woo-
dc.contributor.affiliatedAuthorOh, Jin Hwan-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.contributor.affiliatedAuthorJung, Hyun Ho-
dc.contributor.affiliatedAuthorKim, Jin Hyung-
dc.rights.accessRightsnot free-
dc.citation.volume157-
dc.citation.number6-
dc.citation.startPage1051-
dc.citation.endPage1057-
dc.identifier.bibliographicCitationActa Neurochirurgica, Vol.157(6) : 1051-1057, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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