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Genetic association between VEGF polymorphisms and BRONJ in the Korean population

Authors
 H Choi  ;  JH Lee  ;  J-H Lee  ;  J-H Kim 
Citation
 Oral Diseases, Vol.21(7) : 866-871, 2015 
Journal Title
 Oral Diseases 
ISSN
 1354-523X 
Issue Date
2015
Abstract
OBJECTIVES: The purpose of this study was to evaluate the association between vascular endothelial growth factor (VEGF) polymorphisms and bisphosphonate-related osteonecrosis of the jaw (BRONJ) in the Korean population. SUBJECTS AND METHODS: Forty-five individuals (2 men, 43 women; mean age: 68.7 ± 12.3 years) were recruited for this study. All visited the Yonsei University Dental Hospital for surgical intervention from January 2012 to January 2013 and had a history of bisphosphonate (BP) administration (oral and/or intravenous). Patients were allocated to case (n = 26) or control (n = 19) groups according to the patients' selection criteria. Association between three VEGF single nucleotide polymorphisms (rs699947 (-2578 C>A), rs2010963 (-634 G>C) and rs3025039 (+936 C>T)) and BRONJ were investigated using multiple logistic regression analysis and Fisher's exact test where appropriate (α = 0.05). RESULTS: The CC homozygotes of rs2010963 and rs3025039 of VEGF gene were associated with an increased risk of BRONJ (P = 0.04, 0.03, respectively). In haplotype analysis, no differences in haplotype C-C (-2578/-634) and haplotype C-C-C (-2578/-634/+936) were observed. CONCLUSION: The CC homozygotes of rs2010963 and rs3025039 polymorphisms in the VEGF gene were associated with an increased risk of BRONJ in the Korean population. Further epidemiological cohort studies with a larger sample size would be required to confirm the suggestive correlations.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141539
DOI
10.1111/odi.12355
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소)
Yonsei Authors
김지환(Kim, Jee Hwan) ; 이재훈(Lee, Jae Hoon) ; 이지현(Lee, Ji Hyun) ; 최현민(Choi, Hyun Min)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/odi.12355/abstract
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