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Genetic association between VEGF polymorphisms and BRONJ in the Korean population

DC FieldValueLanguage
dc.contributor.author김지환-
dc.contributor.author이재훈-
dc.contributor.author이지현-
dc.contributor.author최현민-
dc.date.accessioned2016-02-04T11:56:29Z-
dc.date.available2016-02-04T11:56:29Z-
dc.date.issued2015-
dc.identifier.issn1354-523X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141539-
dc.description.abstractOBJECTIVES: The purpose of this study was to evaluate the association between vascular endothelial growth factor (VEGF) polymorphisms and bisphosphonate-related osteonecrosis of the jaw (BRONJ) in the Korean population. SUBJECTS AND METHODS: Forty-five individuals (2 men, 43 women; mean age: 68.7 ± 12.3 years) were recruited for this study. All visited the Yonsei University Dental Hospital for surgical intervention from January 2012 to January 2013 and had a history of bisphosphonate (BP) administration (oral and/or intravenous). Patients were allocated to case (n = 26) or control (n = 19) groups according to the patients' selection criteria. Association between three VEGF single nucleotide polymorphisms (rs699947 (-2578 C>A), rs2010963 (-634 G>C) and rs3025039 (+936 C>T)) and BRONJ were investigated using multiple logistic regression analysis and Fisher's exact test where appropriate (α = 0.05). RESULTS: The CC homozygotes of rs2010963 and rs3025039 of VEGF gene were associated with an increased risk of BRONJ (P = 0.04, 0.03, respectively). In haplotype analysis, no differences in haplotype C-C (-2578/-634) and haplotype C-C-C (-2578/-634/+936) were observed. CONCLUSION: The CC homozygotes of rs2010963 and rs3025039 polymorphisms in the VEGF gene were associated with an increased risk of BRONJ in the Korean population. Further epidemiological cohort studies with a larger sample size would be required to confirm the suggestive correlations.-
dc.description.statementOfResponsibilityopen-
dc.format.extent866~871-
dc.relation.isPartOfORAL DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHBisphosphonate-Associated Osteonecrosis of the Jaw/genetics*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHaplotypes-
dc.subject.MESHHomozygote-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHVascular Endothelial Growth Factor A/genetics*-
dc.titleGenetic association between VEGF polymorphisms and BRONJ in the Korean population-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorH Choi-
dc.contributor.googleauthorJH Lee-
dc.contributor.googleauthorJ-H Lee-
dc.contributor.googleauthorJ-H Kim-
dc.identifier.doi10.1111/odi.12355-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01006-
dc.contributor.localIdA04208-
dc.contributor.localIdA03091-
dc.contributor.localIdA03214-
dc.relation.journalcodeJ02438-
dc.identifier.eissn1601-0825-
dc.identifier.pmid26086871-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/odi.12355/abstract-
dc.subject.keywordbisphosphonate-
dc.subject.keywordbisphosphonate-related osteonecrosis of the jaw-
dc.subject.keywordgene polymorphisms-
dc.subject.keywordvascular endothelial growth factor-
dc.contributor.alternativeNameKim, Jee Hwan-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.alternativeNameLee, Ji Hyun-
dc.contributor.alternativeNameChoi, Hyun Min-
dc.contributor.affiliatedAuthorKim, Jee Hwan-
dc.contributor.affiliatedAuthorChoi, Hyun Min-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.contributor.affiliatedAuthorLee, Ji Hyun-
dc.rights.accessRightsnot free-
dc.citation.volume21-
dc.citation.number7-
dc.citation.startPage866-
dc.citation.endPage871-
dc.identifier.bibliographicCitationORAL DISEASES, Vol.21(7) : 866-871, 2015-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소) > 1. Journal Papers

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