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Validation of 10-Minute Delayed Hepatocyte Phase Imaging with 30° Flip Angle in Gadoxetic Acid-Enhanced MRI for the Detection of Liver Metastasis

Authors
 Dahye Lee  ;  Eun-Suk Cho  ;  Dae Jung Kim  ;  Joo Hee Kim  ;  Jeong Sik Yu  ;  Jae Joon Chung 
Citation
 PLoS One, Vol.10(10) : e0139863, 2015 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2015
Abstract
OBJECTIVES: To compare 10-minute delayed hepatocyte phase imaging using a 30° flip angle (10min-FA30) and 20-minute hepatocyte phase imaging using a 10° FA (20min-FA10) in gadoxetic acid-enhanced MRI of patients with possible liver metastases, regarding lesion-to-liver contrast-to-noise ratio (CNR) and focal hepatic lesion (FHL) detection to evaluate whether 10min-FA30 would be superior to 20min-FA10. MATERIALS AND METHODS: Eighty-three patients with 248 liver metastases and 78 benign FHLs who underwent gadoxetic acid-enhanced MRI with 10min-FA30 and 20min-FA10 were enrolled. Lesion-to-liver CNRs were compared between the two image groups. Two radiologists independently assessed the presence of FHLs using a four-point scale and detection sensitivity was calculated. RESULTS: The mean CNR for liver metastases on the 10min-FA30 (248.5 ± 101.6) were significantly higher than that of the 20min-FA10 (187.4 ± 77.4) (p < 0.001). The mean CNR difference between the two image groups was 61.2 ± 56.8. There was no significant difference in detection sensitivity of FHLs for two readers between 10min-FA30 (mean 97.7%) and 20min-FA10 (mean 97.9%), irrespective of the lesion size or malignancy. CONCLUSION: 10min-FA30 yielded higher CNR with similar sensitivity compared to 20min-FA10. This finding indicates that 10min-FA30 can potentially replace 20min-FA10 with higher diagnostic performance and save 10 minutes of time.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141463
DOI
10.1371/journal.pone.0139863
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김주희(Kim, Joo Hee) ; 유정식(Yu, Jeong Sik) ; 정재준(Chung, Jae Joon) ; 조은석(Cho, Eun Suk)
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