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Meibomian gland dysfunction in Graves' orbitopathy

Authors
 Young Shin Kim  ;  Ae Young Kwak  ;  Sang Yeul Lee  ;  Jin Sook Yoon  ;  Sun Young Jang 
Citation
 CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, Vol.50(4) : 278-282, 2015 
Journal Title
 CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE 
ISSN
 0008-4182 
Issue Date
2015
MeSH
Adult ; Eyelid Diseases/diagnostic imaging ; Eyelid Diseases/etiology* ; Female ; Follow-Up Studies ; Graves Ophthalmopathy/complications* ; Graves Ophthalmopathy/diagnosis ; Healthy Volunteers ; Humans ; Male ; Meibomian Glands/pathology* ; Middle Aged ; Radiography ; Retrospective Studies ; Risk Factors ; Surveys and Questionnaires ; Tears/chemistry
Abstract
OBJECTIVE: To examine morphologic changes in the meibomian glands associated with patients with Graves' orbitopathy (GO) using a novel meibography imaging system, and to evaluate its correlation with GO clinical manifestations. DESIGN: Retrospective, observational case series. PARTICIPANTS: Fifty-one GO patients and 31 normal control participants. METHODS: This retrospective study examined 51 GO patients and 31 normal control participants. The structure of the meibomian gland was assessed using the meibography imaging system. All of the participants completed the Ocular Surface Disease Index (OSDI) questionnaire. The tear film break-up time (BUT) was measured. The palpebral fissure height, exophthalmos, and eyelid retraction were also assessed. RESULTS: The meibography score, tear film BUT, and OSDI indicated statistically significant differences between the GO and normal groups: The tear film BUT was shorter and the OSDI and meibography score were higher in the GO patient group. There was a significant negative correlation between the meibography score and the tear film BUT in GO patients (r = -.503 and p < .001). In the multivariable linear regression analysis, the meibography score of the GO patients had a positive association with exophthalmos and palpebral fissure height. CONCLUSIONS: Compared with the normal control participants, GO patients had more unstable tear films and severe symptoms of dry eye. Using the meibography system, the authors found that GO patients had a higher prevalence of obstructive type meibomian gland dysfunction and changes in meibomian glands increased, with proptosis and lid fissure widening.
Full Text
http://www.sciencedirect.com/science/article/pii/S0008418215002331
DOI
10.1016/j.jcjo.2015.05.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Ae Young(곽애영)
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Lee, Sang Yeul(이상열)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141461
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