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Meibomian gland dysfunction in Graves' orbitopathy

DC FieldValueLanguage
dc.contributor.author곽애영-
dc.contributor.author윤진숙-
dc.contributor.author이상열-
dc.date.accessioned2016-02-04T11:54:22Z-
dc.date.available2016-02-04T11:54:22Z-
dc.date.issued2015-
dc.identifier.issn0008-4182-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141461-
dc.description.abstractOBJECTIVE: To examine morphologic changes in the meibomian glands associated with patients with Graves' orbitopathy (GO) using a novel meibography imaging system, and to evaluate its correlation with GO clinical manifestations. DESIGN: Retrospective, observational case series. PARTICIPANTS: Fifty-one GO patients and 31 normal control participants. METHODS: This retrospective study examined 51 GO patients and 31 normal control participants. The structure of the meibomian gland was assessed using the meibography imaging system. All of the participants completed the Ocular Surface Disease Index (OSDI) questionnaire. The tear film break-up time (BUT) was measured. The palpebral fissure height, exophthalmos, and eyelid retraction were also assessed. RESULTS: The meibography score, tear film BUT, and OSDI indicated statistically significant differences between the GO and normal groups: The tear film BUT was shorter and the OSDI and meibography score were higher in the GO patient group. There was a significant negative correlation between the meibography score and the tear film BUT in GO patients (r = -.503 and p < .001). In the multivariable linear regression analysis, the meibography score of the GO patients had a positive association with exophthalmos and palpebral fissure height. CONCLUSIONS: Compared with the normal control participants, GO patients had more unstable tear films and severe symptoms of dry eye. Using the meibography system, the authors found that GO patients had a higher prevalence of obstructive type meibomian gland dysfunction and changes in meibomian glands increased, with proptosis and lid fissure widening.-
dc.description.statementOfResponsibilityopen-
dc.format.extent278~282-
dc.relation.isPartOfCanadian Journal of Ophthalmology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMeibomian gland dysfunction in Graves' orbitopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorYoung Shin Kim-
dc.contributor.googleauthorAe Young Kwak-
dc.contributor.googleauthorSang Yeul Lee-
dc.contributor.googleauthorJin Sook Yoon-
dc.contributor.googleauthorSun Young Jang-
dc.identifier.doi10.1016/j.jcjo.2015.05.012-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00171-
dc.contributor.localIdA02611-
dc.contributor.localIdA02819-
dc.relation.journalcodeJ00431-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0008418215002331-
dc.contributor.alternativeNameKwak, Ae Young-
dc.contributor.alternativeNameYoon, Jin Sook-
dc.contributor.alternativeNameLee, Sang Yeul-
dc.contributor.affiliatedAuthorKwak, Ae Young-
dc.contributor.affiliatedAuthorYoon, Jin Sook-
dc.contributor.affiliatedAuthorLee, Sang Yeul-
dc.rights.accessRightsnot free-
dc.citation.volume50-
dc.citation.number4-
dc.citation.startPage278-
dc.citation.endPage282-
dc.identifier.bibliographicCitationCanadian Journal of Ophthalmology, Vol.50(4) : 278-282, 2015-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)

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