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Retinoic Acid-induced Differentiation of Rat Mesenchymal Stem Cells into β-Cell Lineage

DC FieldValueLanguage
dc.contributor.author김경식-
dc.contributor.author김유선-
dc.contributor.author김재형-
dc.contributor.author김현우-
dc.contributor.author서활-
dc.contributor.author이상우-
dc.contributor.author주동진-
dc.date.accessioned2016-02-04T11:53:17Z-
dc.date.available2016-02-04T11:53:17Z-
dc.date.issued2015-
dc.identifier.issn1598-1711-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141422-
dc.description.abstractBackgrounds: Type I diabetes mellitus (T1DM), an autoimmune disease, is associated with insulin deficiency due to the death of β-cells. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are capable of tissue repair and thus are a promising source of β-cell surrogates. Methods: In this study, the therapeutic potential of BM-MSCs as β-cell replacements was analyzed both in vitro and in vivo. First, we used retinoic acid (RA) to induce rat BM-MSCs to differentiate into cells of endodermal/pancreatic lineage. Then, differentiated rat BM-MSCs were syngeneically injected under the renal capsule of rats. Results: Analysis of gene expression revealed that rat BM-MSCs showed signs of early pancreatic development, and differentiated cells were qualitatively and quantitatively confirmed to produce insulin in vitro. In vivo study was performed for short-term (3 weeks) and long-term (8 weeks) period of time. Rats that were injected with differentiated MSCs exhibited a reduction in blood glucose levels throughout 8 weeks, and grafted cells survived in vivo for at least 3 weeks. Conclusions: These findings show that RA can induce differentiation of MSCs into the β-cell lineage and demonstrate the potential of BM-MSCs to serve as therapeutic tools for T1DM.-
dc.description.statementOfResponsibilityopen-
dc.format.extent118~129-
dc.relation.isPartOfJournal of the Korean Society for Transplantation-
dc.relation.isPartOf대한이식학회지-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRetinoic Acid-induced Differentiation of Rat Mesenchymal Stem Cells into β-Cell Lineage-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJaehyung Kim-
dc.contributor.googleauthorKyungsik Kim-
dc.contributor.googleauthorSangwoo Lee-
dc.contributor.googleauthorHyunwoo Kim-
dc.contributor.googleauthorDongjin Joo-
dc.contributor.googleauthorYuseun Kim-
dc.contributor.googleauthorHwal Suh-
dc.identifier.doi10.4285/jkstn.2015.29.3.118-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00299-
dc.contributor.localIdA00785-
dc.contributor.localIdA01924-
dc.contributor.localIdA02821-
dc.contributor.localIdA03948-
dc.contributor.localIdA00873-
dc.contributor.localIdA01124-
dc.relation.journalcodeJ01858-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameKim, Jae Hyung-
dc.contributor.alternativeNameKim, Hyun Woo-
dc.contributor.alternativeNameSuh, Hwal-
dc.contributor.alternativeNameLee, Sang Woo-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorSuh, Hwal-
dc.contributor.affiliatedAuthorLee, Sang Woo-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorKim, Jae Hyung-
dc.contributor.affiliatedAuthorKim, Hyun Woo-
dc.rights.accessRightsfree-
dc.citation.volume29-
dc.citation.number3-
dc.citation.startPage118-
dc.citation.endPage129-
dc.identifier.bibliographicCitationJournal of the Korean Society for Transplantation (대한이식학회지), Vol.29(3) : 118-129, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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