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Retinoic Acid-induced Differentiation of Rat Mesenchymal Stem Cells into β-Cell Lineage
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경식 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 김재형 | - |
dc.contributor.author | 김현우 | - |
dc.contributor.author | 서활 | - |
dc.contributor.author | 이상우 | - |
dc.contributor.author | 주동진 | - |
dc.date.accessioned | 2016-02-04T11:53:17Z | - |
dc.date.available | 2016-02-04T11:53:17Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1298-1711 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141422 | - |
dc.description.abstract | Backgrounds: Type I diabetes mellitus (T1DM), an autoimmune disease, is associated with insulin deficiency due to the death of β-cells. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are capable of tissue repair and thus are a promising source of β-cell surrogates. Methods: In this study, the therapeutic potential of BM-MSCs as β-cell replacements was analyzed both in vitro and in vivo. First, we used retinoic acid (RA) to induce rat BM-MSCs to differentiate into cells of endodermal/pancreatic lineage. Then, differentiated rat BM-MSCs were syngeneically injected under the renal capsule of rats. Results: Analysis of gene expression revealed that rat BM-MSCs showed signs of early pancreatic development, and differentiated cells were qualitatively and quantitatively confirmed to produce insulin in vitro. In vivo study was performed for short-term (3 weeks) and long-term (8 weeks) period of time. Rats that were injected with differentiated MSCs exhibited a reduction in blood glucose levels throughout 8 weeks, and grafted cells survived in vivo for at least 3 weeks. Conclusions: These findings show that RA can induce differentiation of MSCs into the β-cell lineage and demonstrate the potential of BM-MSCs to serve as therapeutic tools for T1DM. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 118~129 | - |
dc.language | Journal of the Korean Society for Transplantation | - |
dc.publisher | Journal of the Korean Society for Transplantation | - |
dc.relation.isPartOf | Journal of the Korean Society for Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Retinoic Acid-induced Differentiation of Rat Mesenchymal Stem Cells into β-Cell Lineage | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Jaehyung Kim | - |
dc.contributor.googleauthor | Kyungsik Kim | - |
dc.contributor.googleauthor | Sangwoo Lee | - |
dc.contributor.googleauthor | Hyunwoo Kim | - |
dc.contributor.googleauthor | Dongjin Joo | - |
dc.contributor.googleauthor | Yuseun Kim | - |
dc.contributor.googleauthor | Hwal Suh | - |
dc.identifier.doi | 10.4285/jkstn.2015.29.3.118 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A01924 | - |
dc.contributor.localId | A02821 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A00873 | - |
dc.contributor.localId | A01124 | - |
dc.relation.journalcode | J01858 | - |
dc.identifier.eissn | 2508-2604 | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Kim, Jae Hyung | - |
dc.contributor.alternativeName | Kim, Hyun Woo | - |
dc.contributor.alternativeName | Suh, Hwal | - |
dc.contributor.alternativeName | Lee, Sang Woo | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Suh, Hwal | - |
dc.contributor.affiliatedAuthor | Lee, Sang Woo | - |
dc.contributor.affiliatedAuthor | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hyung | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Woo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 118 | - |
dc.citation.endPage | 129 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Transplantation, Vol.29(3) : 118-129, 2015 | - |
dc.identifier.rimsid | 30635 | - |
dc.type.rims | ART | - |
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