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Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats

 Seong Jun Ryu  ;  Dal Sung Ryu  ;  Jong Yul Kim  ;  Jeong Yoon Park  ;  Kyung Hyun Kim  ;  Dong Kyu Chin  ;  Keun Su Kim  ;  Yong Eun Cho  ;  Sung Uk Kuh 
 Korean Journal of Spine, Vol.12(2) : 55-59, 2015 
Journal Title
 Korean Journal of Spine 
Issue Date
OBJECTIVE: To investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking. METHODS: Twenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups: a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery. RESULTS: Femoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery. CONCLUSION: 8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
구성욱(Kuh, Sung Uk) ORCID logo https://orcid.org/0000-0003-2566-3209
김경현(Kim, Kyung Hyun)
김근수(Kim, Keun Su) ORCID logo https://orcid.org/0000-0002-3384-5638
김종열(Kim, Jong Yul)
류달성(Ryu, Dal Sung)
박정윤(Park, Jeong Yoon) ORCID logo https://orcid.org/0000-0002-3728-7784
조용은(Cho, Yong Eun) ORCID logo https://orcid.org/0000-0001-9815-2720
진동규(Chin, Dong Kyu) ORCID logo https://orcid.org/0000-0002-9835-9294
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