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Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats

 Seong Jun Ryu  ;  Dal Sung Ryu  ;  Jong Yul Kim  ;  Jeong Yoon Park  ;  Kyung Hyun Kim  ;  Dong Kyu Chin  ;  Keun Su Kim  ;  Yong Eun Cho  ;  Sung Uk Kuh 
 Korean Journal of Spine, Vol.12(2) : 55-59, 2015 
Journal Title
 Korean Journal of Spine 
Issue Date
OBJECTIVE: To investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking. METHODS: Twenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups: a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery. RESULTS: Femoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery. CONCLUSION: 8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
구성욱(Kuh, Sung Uk) ; 김경현(Kim, Kyung Hyun) ; 김근수(Kim, Keun Su) ; 김종열(Kim, Jong Yul) ; 류달성(Ryu, Dal Sung) ; 박정윤(Park, Jeong Yoon) ; 조용은(Cho, Yong Eun) ; 진동규(Chin, Dong Kyu)
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