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Development of Thyroid-Associated Ophthalmopathy in Patients Who Underwent Total Thyroidectomy

 Sun Young Jang  ;  Ka Hyun Lee  ;  Jong Rok Oh  ;  Bo Yeon Kim  ;  Jin Sook Yoon 
 YONSEI MEDICAL JOURNAL, Vol.56(5) : 1389-1394, 2015 
Journal Title
Issue Date
Adult ; Aged ; Autoantibodies/blood ; Carcinoma ; Carcinoma, Papillary/immunology ; Carcinoma, Papillary/surgery ; Female ; Graves Ophthalmopathy/diagnosis* ; Graves Ophthalmopathy/immunology ; Humans ; Male ; Middle Aged ; Postoperative Complications/etiology ; Postoperative Complications/immunology ; Postoperative Complications/pathology ; Receptors, Thyrotropin ; Retrospective Studies ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/surgery* ; Thyroidectomy/adverse effects ; Thyroidectomy/methods* ; Thyrotropin/blood ; Treatment Outcome
TSH receptor autoantibody ; Total thyroidectomy ; thyroid benign mass ; thyroid cancer ; thyroid-associated orbitopathy
PURPOSE: To report clinical characteristics of thyroid-associated ophthalmopathy (TAO) in patients who previously underwent total thyroidectomy for thyroid cancer or a benign mass of the thyroid. MATERIALS AND METHODS: Of the patients who were diagnosed with TAO from March 2008 to March 2012, we performed a retrospective chart review on those who had undergone total thyroidectomy for thyroid cancer or a benign mass of the thyroid before the occurrence of ophthalmopathy. RESULTS: Of the 206 patients diagnosed with TAO, seven (3.4%) met the inclusion criteria. The mean age of the subjects was 47.4 years, and all were female. Six patients were diagnosed with papillary thyroid cancer, and one was diagnosed with a benign mass. The duration between total thyroidectomy and onset of TAO ranged from 3-120 months (median 48 months). Ophthalmic manifestations varied among cases. Except for the patient who was diagnosed with a benign mass, all patients showed hyperthyroid status and were under Synthroid hormone treatment at the time of TAO development. Five of these six patients had positive levels of thyroid-stimulating hormone (TSH) receptor autoantibodies. CONCLUSION: TAO rarely develops after total thyroidectomy, and the mechanism of TAO occurrence is unclear. However, most patients showed abnormalities in thyroid function and TSH receptor autoantibodies.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
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